This is a story about a 20-year-old first-year college student, Botan Kamiina, and her life in a dorm, where she meets her seniors and forms friendships through drinking sessions. The anime features many real-life alcoholic drinks - Japanese sake, whiskey, wine - and also describes music, movies, and other cultural elements that can be enjoyed with alcohol. Each drink and pastime is closely tied to the characters' personalities and emotions, creating a special atmosphere.

Shizuku Kanzaki is the only son of world-renowned wine critic Yutaka Kanzaki. From a young age, Shizuku has been subjected to strange education from his father all for the sake of wine. From learning to gracefully decant a drink to intently remembering the smell of leather belts and pencils, the training causes him to grow resentful of everything related to wine. Discontent with his father, he leaves home to become an average sales representative for a beer company, refusing to ever touch wine again. When his father suddenly passes away, Shizuku finds himself being dragged back into the world he hates so much. As part of his father's will, the one who will inherit his prized wine collection and estate will be the person who can correctly identify the 12 Apostles of wines as well as the legendary Drops of God. In order to inherit the assets, Shizuku has one year to complete the task, but he finds the proposition ridiculous when he is the only living relative of Yutaka. What Yutaka failed to tell his son before his death was that he had adopted Issei Tomine into the family a week prior to his passing. Issei is a famous veteran wine critic competing against Shizuku to claim the estate for himself. With no formal training in wine tasting, Shizuku stands no chance against The Prince of Wine and is at risk of losing everything in this competition. Will he be able to correctly identify the elusive Drops of God before he runs out of time?

On the surface, high school student Koyuki Koyun Hikawa seems unapproachable and terrifying to most other students. In reality, Koyun is just insecure and prone to overthinking due to her uncomfortable experiences in middle school. However, her chance encounter with two boys in school—Minato Amamiya and Youta Hino—sparks a change in her. Like her friend Miki Azumi, the boys are never afraid to approach Koyun and see her for who she really is. Although Koyun starts spending more time with Miki, Minato, and Youta, she finds herself torn between her newfound bliss and her fear of getting too attached to others. Meanwhile, each of her friends quietly struggles with their own challenges. But as the new friend group continues to navigate high school together, Koyun and the others start to break out of their shells and enjoy their adolescence to the fullest.

Obsessed with their rather ordinary classmate Ken Kirio, high school students Aimi Miyoshi and Nami Sometani form a peculiar friendship. Every time the girls hang out, they talk about Kirio and fantasize about interacting with the boy they usually just observe from afar. Aimi and Nami are mostly satisfied with the status quo, but they occasionally cannot help but be jealous of those who get to be near their crush—though this still rarely leads them to approach him directly.