Yachiyo Inugami, a cat-loving extrovert, and Suzu Nekoyama, a dog-loving introvert, are unexpectedly cast into a relationship on a day like any other. The pair find themselves drawn together through an inexplicable attraction of their opposite personalities. As they quickly begin to understand one another, Inugami's hardened resolve to gain Nekoyama's favor only leads to frenzied responses. Soon after their momentous union, the two begin to spend more time with one another, growing closer all the while. Their combined antics gain the attention of the mousy Mikine Nezu, a classmate of Inugami, and soon they join the biology club. There, they meet Ushikawa Ukiji, a passive, cow-like upperclassmen. Nezu and Nekoyama soon begin to build upon their relationship and a game of cat and mouse soon begins. Wild, explosive, and vibrant, Inugami-san to Nekoyama-san tells the comedic tale of two high school girls and their less-than-normal relationship.

Haruki Nakano lives an average high school life, except for the fact that his mother is overseas and he shares an apartment with his four sisters. There's the oldest, Mutsuki, who has a bad habit of falling asleep in his bed, the junior high school student Yayoi, who hits him whenever something happens, and then the grade school twins, Uzuki and Satsuki, who love to play pranks on their older brother. Stuck in a house with four girls, Haruki has to deal with all sorts of trials. From going grocery shopping, watching scary movies, to kissing practice, life is never boring in Danchigai!

The anime adaptation of the four-panel manga Ai Mai Mii. The story follows girls in a manga club—Ai, Mai, Mii, and Ponoka-senpai—who might be fighting evil invaders threatening Earth, facing off against rivals in tournaments, and dealing with other absurd situations when they are not drawing manga. (Source: ANN)

Second season of Ai Mai Mii.