Shun Asanaga is a 15-year-old junior high school student with an optimistic and bright personality. One day, he finds a mysterious crystal in the office of his father, who is a scientist and businessman. When Shun touches it, the world becomes distorted, and he is sent into the world of Endra. Emilio, a prince of the kingdom of Endra, is nearing his 16th birthday and despises the reigning king, Delzain. Since Emilio is now at the age when he can inherit the throne, he takes up a weapon and attempts revenge. However, because Emilio is too weak, he is captured by Delzain and put in prison. When Emilio is in grief, the wall of his cell becomes distorted and Shun appears from there with two goals: return to his own world, and complete Emilio's revenge. What future lies ahead for the two boys trying to survive in Endra, yet raised in two different worlds? (Source: MAL News)

The story takes place in Japan. The year is 2030 and Earth has been completely overrun by a viral disease named Gibia that turns infected people into various different monsters, based on their age, sex, and race. A samurai and a ninja from the early Edo period travel together through time and arrive in a ruined Japan to aid a professor working on a cure for the virus. Together, they fight countless Gibia monsters, outlaws, and other fierce foes on their journey to save mankind.

Naoya Mukai is having the time of his life after his childhood friend Saki Saki finally accepts one of his countless confessions. Ensuring that their relationship will stay strong, he spares no effort in showering affection to his now beloved girlfriend. However, one afternoon, another girl named Nagisa Minase suddenly confesses to Naoya following months of preparation. Even though he politely rejects her, Nagisa's irresistible charm and determination continue to attract Naoya. Wanting to fulfill both Saki and Nagisa's desires, Naoya ends up proposing a crazy idea—to date the two of them simultaneously, with both girls fully aware. This unprecedented state of affairs ultimately causes wacky and hilarious situations in whatever they do to keep their unusual relationship going.

All of a sudden, they arrived: parasitic aliens that descended upon Earth and quickly infiltrated humanity by burrowing into the brains of vulnerable targets. These insatiable beings acquire full control of their host and are able to morph into a variety of forms in order to feed on unsuspecting prey. Sixteen-year-old high school student Shinichi Izumi falls victim to one of these parasites, but it fails to take over his brain, ending up in his right hand instead. Unable to relocate, the parasite, now named Migi, has no choice but to rely on Shinichi in order to stay alive. Thus, the pair is forced into an uneasy coexistence and must defend themselves from hostile parasites that hope to eradicate this new threat to their species.