For centuries, the Iga and Kouga ninja clans have engaged in a bitter war. But when a ceasefire is ordered by the powerful warlord Ieyasu Tokugawa, the two clans are forced to put down their arms. Years later, Gennosuke Kouga, heir of the Kouga clan, and Oboro Iga, heir of the Iga clan, have fallen in love. Through marriage, both heirs aim to bring peace to the clans. But their hopes are dashed when flames of rivalry between their clans are reignited, and they are dragged into another war. Ieyasu's two grandsons have both claimed to be the next heir to the shogunate. To resolve this dispute, both the Kouga and Iga are ordered to send their 10 best warriors to fight in a bloody battle royale, with each clan representing one of the potential shogunate heirs. Two scrolls with the names of the fighters are given and are to be marked in blood upon the given fighter's death. The prize for winning is the favor of the Tokugawa shogunate for a thousand years. Torn between their love for each other and duty to their clans, Gennosuke and Oboro must ultimately decide the fate of their clans.

Modern Germany is plagued by an outbreak of Amalgams. Existing solely to wreak havoc, these cybernetic entities spawn from rotting flesh and can fuse with technology to gain new abilities. With society left in the wake of their destruction, the Xenogenesis Assault Team (XAT) is formed to suppress the threat. Alongside its primary mission to protect against the Amalgam attacks, the organization is also researching the newly discovered amalgamated humans which possess rational thought and are far deadlier than their non-sentient counterparts. Joseph Jobson is one such amalgamated human who has full control over his powers. Although successful in his line of work as a lone warrior, an unfortunate encounter with the recently-turned-Amalgam Gerd Frentzen makes him a priority target of the XAT. As he eludes the organization and seeks new allies, Joseph is transformed into the Blassreiter—a being heralded as the strongest Amalgam in existence. Now, he must fight back with his newfound powers to uncover the truth behind not only his past, but also the entire Amalgam conflict.

In the year 5053, French aristocrats Viscount Albert de Morcerf and Baron Franz d'Epinay attend the festival of Carnival on the moon city of Luna. While Franz is just looking to have fun, Albert is seeking something more to fill his life—but he finds more than he bargained for in The Count of Monte Cristo, a mysterious and charming self-made nobleman who meets his gaze during an opera performance. Through a few twists and turns, Albert befriends the Count and introduces him into French society. The Count, however, has more on his mind than just friendship; he plots to finally unleash his vengeance on those who wronged him years earlier. Gankutsuou follows Albert and the Count's intertwined destinies and the ultimate price paid for enacting revenge.

An animated spin-off from the Densha Otoko (Trainman) TV drama. In the drama, actor Itoh Atsushi plays the otaku Yamada, whose main love in life is the Mina anime, a cutesy busty heroine with floppy rabbit ears and carrots sticking out her rear. Mina itself is a character homage which triggers back to the Daicon Animation done by GAINAX where a similar nameless bunny girl appeared. Densha Otoko futher featured an opening with scenes which were appearing back in the Daicon Animation. (Source: AniDB)