After a year in grade school without her childhood friends, first year student Akari Akaza is finally reunited with second years Yui Funami and Kyouko Toshinou at their all-girls' middle school. During the duo's first year, Yui and Kyouko formed the Amusement Club which occupies the now nonexistent Tea Club's room. Shortly after Akari joins, one of her fellow classmates, Chinatsu Yoshikawa, pays the trio a visit under the impression that they are the Tea Club; it is only once the three girls explain that the Tea Club has been disbanded that they can convince Chinatsu to join the Amusement Club—a group with no purpose other than to provide entertainment for its members. Based on the slice-of-life manga by Namori, Yuru Yuri is an eccentric comedy about a group of girls who spend their spare time drinking tea and fawning over each other, all while completely failing to even notice the supposed main character Akari amongst them.

Feelings may come and go, but true love always remains in the heart. Tsumiki Miniwa is in love with her best friend, Io Otonashi. For her, confessing is nearly impossible; but to her friends, they seem to be the perfect match. Cute and petite, Tsumiki comes off more as a friend, and Io's attitude toward her is friendlier than toward others. Despite the constant teasing and obvious hints that his friends have been dropping, Io always seems to miss the signs. Throughout her everyday school life, Tsumiki spends time with her friends and Io. Will she finally muster enough courage to confess her true feelings?

College student Yuuhi Amamiya's monotonous life is turned upside down with the appearance of Sir Noi Crezant, a talking lizard claiming to be a knight of justice. Crezant elaborates that the world is in peril—threatened by the mage Animus who wishes to annihilate it with his Biscuit Hammer, an enormous structure suspended in Earth's orbit. As the newly appointed Lizard Knight, Yuuhi must fight alongside other Beast Knights to protect the princess and save the planet from destruction. Unimpressed by the prospect of risking his life, Yuuhi continues his day as usual—until a golem created by Animus suddenly confronts him. Yuuhi is instantly overpowered, but his neighbor, Princess Samidare Asahina, luckily rescues him. To his surprise, Samidare's intention starkly differs from Crezant's; instead of saving the world, she aims to destroy it with her own hands. Captivated by her firm ambition, Yuuhi resolves to become stronger and help Samidare realize her goal. As the pair continues to fight against Animus' golems, Yuuhi finds himself gradually gaining an interest in life—but the chains of his past trauma may restrain him from progressing further.

Kazuma Hoshino is preparing himself for a new stage of his life as a teenager. Because of his brother Ayumu's weaker than average health, their parents thought it best for the family to move out from the city to a more rural environment. Now the two brothers are off to the Yorozuyo Inn where they’ll be staying until their parents can settle affairs back in the city and set up their new home. Their arrival to the inn doesn't go as planned though when they catch the wrong bus, wind up in the middle of nowhere, Ayumu gets his hat stolen by a wild monkey, and Kazuma gets lost in the woods trying to track the animal down. It all leads to a chance encounter with a spirited young girl named Ui, who Kazuma ends up accidentally falling onto and kissing while she tries leading him back to the bus stop. This hardly sits well with Ui’s friend Ibuki who swiftly kicks Kazuma and sends him on his way. Much to Kazuma's continued horror, his bad luck is perpetuated at the inn thanks to its landlady Senka and her slightly perverted sense of humor, and then finding out that two of his classmates are the girls he embarrassed himself in front of back in the woods! Hoshizora e Kakaru Hashi finds Kazuma adapting to his new school, dealing with the multiple women who have entered his life, providing emotional support for his younger brother, and coping with living with his new landlady. However, for some reason, something about this place is bringing whispers of the past into Kazuma's mind. Small flashes back to a more innocent time and a friendship long forgotten. What could this déjà vu mean?