Deep in the deserts of southwestern United States lies Neo Purgatory. Formerly a nuclear waste disposal site, the facility has been turned into a prison for hardened criminals; that is, until the prisoners weaponize the nuclear waste and riot, turning Neo Purgatory into an international disaster. Maki Aoba, Doris Nicholas, Marilyn Moreau, and Naomi Jones make up the Guard of Rose, an all-female special police task force. Along with stowaway Katherine Hook and multi-purpose robot Link, the Guard of Rose is on patrol investigating rumors of an angel near Neo Purgatory when their helicopter is shot down. As the crisis within the prison rapidly devolves, the Guard of Rose members might be the only ones who can stop the prisoners before they unleash nuclear armageddon.

The story is set in the future on the planet named Amoi which is controlled by a supercomputer named Jupiter. Among the mostly male human population, the light-haired elite class is allowed to temporarily keep the dark-haired mongrels as pets. One elite member, Iason, encounters a mongrel named Riki in the slums and decides to take him in. However, Iason keeps Riki longer than it is socially approved, and rumors abound about their possible relationship.

In the distant future, monsters and inhumans roam the land, and the ruling Evil King seeks a human woman to bear him powerful, force-adept heirs. Non offers herself to the Evil King in order to save her village from Ape Clan raiders, and gives him twin sons, Loof and Jin. She and her sons are exiled by the ungrateful villagers, however, and Non's companion Nue (a Demon Clan member changed into a wolf for disobedience) takes Loof to be raised by his father, the Evil King. The Evil One's Queen Parome despises humans, however, and her malevolence towards Loof deepens... (Source: AnimeNfo)

Kazuna's family has a history of suffering from a disease that creates an uncontrollable vampire-like thirst for blood. Knowing none of this, Kazuna was sent to live with the Eda couple as a child. As the sickness begins to show signs of being present within himself, he comes into contact with his older sister, Chizuna, who has been suffering from it since early childhood. Knowing that the sickness incurs a heavy weight upon those that suffer from it, Chizuna tries to ease her brother's burden, to help him learn to control his urges, but... (Source: ANN)