Osamu and Youko Sonoyama want more than anything to adopt every child from Soramame House, but the wealthy couple can only pick one due to their increasingly old age. While they contemplate this delicate decision, one child's alluring beauty and gentle soul instantly draw them in. Two months later, the Sonoyamas welcome 13-year-old Hitori into their warm and loving home. However, Hitori's humble and overly polite exterior is merely a masquerade. In reality, Hitori is a carefully crafted character played by identical twins Migi and Dali. For them, being the ideal child of this kind couple is merely a stepping stone to infiltrating a certain quiet town. While dutifully protecting their cover, the twins work toward their true objective: to discover the truth behind a past incident that left them with a burning desire for vengeance.

Himari Kino is a cheerful and outgoing girl who is able to make friends with anyone she wants. When she enrolls in high school and attends the freshman opening ceremony, Himari falls in love with Yori Asanagi, a reserved upperclassman, during Yori's band performance. After the show, Himari blurts out her love, but Yori is inexperienced when it comes to romance. Yori, who did not expect this outcome at all, looks for answers from her friends and music. She decides to respond to Himari's confession, and to her surprise, Yori discovers that Himari fell in love with her music and performance rather than Yori as a person. Despite the shock, Yori desires to make Himari truly fall in love with her. The duo spend time together after school on the rooftop, where Yori usually plays her guitar with hopes to change Himari's feelings for her.

Reiji Kirio, formerly a corporate slave, wakes up one day in another world. After discovering that he has gained superhuman pharmaceutical knowledge, he decides to open up a drugstore alongside the canine Noera and the ghostly Mina. There, he tends to the needs of all who visit the shop with potions and the like. Cheat Kusushi no Slow Life: Isekai ni Tsukurou Drugstore follows the slow but often hectic days of Reiji's drugstore.

Inako is a minor country, enclosed by two superior countries: the militaristic Milidonia, with its goal of conquering as much land as possible, and the monotheiestic Selenfalen, devoted to the deity Saint Philia. Ani Inako is the sole princess of her country, and in order to eliminate hostility between the three countries, she is sent as Inako's representative to a peace treaty signing in Selenfalen. However, Ani's hopes of a smooth ceremony are shattered when she meets the eccentric princes from her rival countries. With the treaty binding the three countries together, Ani and the princes must learn to overcome their differences. Together, they search for common ground on which to develop their friendship.