Nestled away on the rooftop of Tenikai General Hospital is the unconventional Department of Investigative Pathology headed by the eccentric Dr. Takao Ameku. The tiny department, consisting of Takao and her sole resident Yuu Kotori Takanashi, treats complex cases that most other departments within the hospital cannot resolve on their own. The mystery-obsessed Takao always tries to insert herself into cases that capture her fancy—much to the dismay of her colleagues and the police. Even if her meddling creates more problems for the hospital and those around her, none can deny the brilliance that the young department head exhibits as she weaves a diagnosis together. No matter the specialty, no case is impossible for Takao and a somewhat reluctant Takanashi to solve.

Driven by conflicting interest groups, the anti-magic movement is gaining dangerous momentum. Warned by the Yotsuba family, Tatsuya Shiba takes countermeasures to foil the plans of crooked politicians and corrupt journalists. He repels the first attack, which framed First High School as an unofficial venue for military education, but his most formidable enemies have yet to act. If Tatsuya wants to preserve his peaceful life with his sister, Miyuki, he must demonstrate once more that no one in the world can outsmart him.

A new tournament, Squad Jam 3, has been announced in the popular VR game Gun Gale Online. This time, Pitohui, one of the best performers in the previous competition, offers to team up with Karen Kohiruimaki, better known in-game as LLENN, the Pink Devil. Despite her initial reluctance, Karen agrees to join Pitohui's team, LPFM, since she looks forward to facing SHINC, her rivals from the previous Squad Jam. The newly formed LPFM enrolls in the tournament and is quickly recognized as the favorite to win due to the caliber of its players. As they strive to come out on top and win Squad Jam 3, LLENN, Pitohui, and the other members of LPFM battle against other competitors and tackle unexpected challenges.

Five years ago, gravity-defying bubbles with mysterious powers rained down upon the earth. After a huge explosion of uncertain origin, Tokyo became ground zero, with the city being enclosed in a gigantic bubble. As a result of this Bubble Fall phenomenon, the metropolis that was once the capital of Japan drowned in a gravity-bending sea; the government declared it a prohibited zone, and the residents abandoned it. Children orphaned by the Bubble Fall now squat illegally in Tokyo, partaking in dangerous parkour team battles across the city's dilapidated buildings. Hibiki—a talented ace in these games with the ability to jump between bubbles—claims he can hear sounds from the Tokyo Tower. Determined to uncover its mysteries, he sets off toward the source, but he falls into the waters below. A strange girl, whom he later nicknames Uta, saves him. But little does Hibiki know that Uta's appearance in his life will reveal the secrets behind the disastrous event that changed their world forever.