Second part of Enen no Shouboutai: San no Shou.

In the American Old West, the world's greatest race is about to begin. Thousands line up in San Diego to travel over six thousand kilometers for a chance to win the grand prize of fifty million dollars. With the era of the horse reaching its end, contestants are allowed to use any kind of vehicle they wish. Competitors will have to endure grueling conditions, traveling up to a hundred kilometers a day through uncharted wastelands. The Steel Ball Run is truly a one-of-a-kind event. The youthful Johnny Joestar, a crippled former horse racer, has come to San Diego to watch the start of the race. There he encounters Gyro Zeppeli, a racer with two steel balls at his waist instead of a gun. Johnny witnesses Gyro using one of his steel balls to unleash a fantastical power, compelling a man to fire his gun at himself during a duel. In the midst of the action, Johnny happens to touch the steel ball and feels a power surging through his legs, allowing him to stand up for the first time in two years. Vowing to find the secret of the steel balls, Johnny decides to compete in the race, and so begins his bizarre adventure across America on the Steel Ball Run.

Teenage delinquent Takeru Narihira has been having a recurring dream where he is chased by monsters, only for a mysterious girl to always rescue him. Having fallen in love with her, he promises her on their 1,999th meeting that he will be the one to save her the next time. But a motorcycle accident sends Takeru to Denji Heian-kyo—an alternate version of Japan's ancient capital with futuristic technology and the home of the girl from his dreams, Tsukiyima, who does not recognize him. However, a black mist soon descends upon the city, petrifying citizens and unleashing monsters called oni. Only the so-called onmyouji—sorcerers who wield mystical powers and pilot magical shikigami suits—can fight them. When the mist returns, Takeru discovers that he has strange transformation powers and can resist the oni. But he and Tsukimiya are ultimately killed, and Takeru awakens in Denji Heian-kyo once again, this time two weeks before the appearance of the mist. Swearing to protect Tsukimiya at all costs, Takeru vows to become an onmyouji and change the future.

With the conclusion of her favorite romance manga, Fuuko Izumo is ready to end her life of misery and loneliness having long accepted her fate of never being able to experience passionate love like fictional characters. Cursed with unluck, anyone Fuuko touches is in grave danger of experiencing unimaginable calamity. While the possibility of imminent danger would have most sane people run in the opposite direction, Undead has other ideas. He is an immortal being with superhuman regenerative powers desperately seeking death, which has always eluded him. When their paths finally cross, Undead sees an opportunity to finally end his suffering by using Fuuko's unluck. But before Undead can unlock the full potential of Fuuko's power to trigger the final devastating blow, the duo must first fend off a murderous secret organization hell-bent on exterminating those with special abilities.