Panty and Stocking Anarchy, the angel twin sisters, have even more ghosts to exorcize in Daten City, thanks to the failed opening of the Hell Gate. They must continue their ghost hunt alongside their longtime rivals, the sisters Scanty and Kneesocks Demon, who must earn Hell Coins to return to Hell. On top of that, the Demon sisters are staying at the church with Garterbelt, the priest in charge of the Anarchy sisters. These two polar opposite duos will have to set aside their differences if they wish to collect enough Heaven and Hell Coins to complete their mission and return to their respective realms.

Adventuring knight Laios Touden leads a small party through a seemingly endless dungeon, a subterranean maze full of dangerous monsters and precarious traps. Through the use of advanced magic, an explorer can sometimes be resurrected, allowing them to learn from past mistakes and give traversing the dungeon another go. However, when a powerful dragon eats Falin, Laios' spellcasting sister, she sends her brother and his companions back to the beginning to save them from permanent ends. Though strapped for cash and equipment, Laios resolves to fight his way through the dungeon and rescue Falin before she can be digested by the dragon. Despite some of Laios' allies abandoning him, two remain by his side: elven mage Marcille Donato and halfling locksmith Chilchuck Tims. Due to their lack of funds, the party faces the daunting prospect of starving before being able to complete their quest. However, they find salvation in Senshi, a dwarven warrior with a penchant for cooking and safely eating defeated monsters. With Senshi's culinary expertise, Laios and his companions struggle through the dungeon while learning about gourmet dining—and each other—along the way.

Throughout history, humans have been at odds with Beastmen—a species capable of changing shape due to their genetic Beast Factor. Because of this conflict, Beastmen have been forced into hiding. Anima City serves as a safe haven for these oppressed individuals to live free from human interference. During a festival celebrating the town's 10th anniversary, Michiru Kagemori, a human who suddenly turned into a tanuki, finds that Anima City is a far cry from paradise. After witnessing an explosion in the square, she is confronted by Shirou Ogami, a seemingly indestructible wolf and sworn protector of all Beastmen. As they pursue the criminals behind the bombing, the two discover that Michiru is anything but an ordinary Beastman, and look to investigate her mysterious past and uncanny abilities. Could she turn out to be the missing link between Humans and Beastmen?

Dreams are doomed to die in Night City, a futuristic Californian metropolis. As a teenager living in the city's slums, David Martinez is trying to fulfill his mother's lifelong wish for him to reach the top of Arasaka, the world's leading security corporation. To this end, he attends the prestigious Arasaka Academy while his mother works tirelessly to keep their family afloat. When an incident with a street gang leaves David's life in tatters, he stumbles upon Sandevistan cyberware—a prosthetic that grants its wearer superhuman speed. Fueled by rage, David implants the device in his back, using it to exact revenge on one of his tormentors. This gets him expelled from the academy, shattering his hopes of ever making his mother proud. After witnessing David's newfound abilities, the beautiful data thief Lucyna Lucy Kushinada offers to team up with him, handing him a ticket to salvation. However, associating with Lucy introduces David to the world of Edgerunners—cyborg criminals who will break any law for money. Edgerunners often lose their lives, if the cyberware does not break their minds first; but in his fight for survival inside a corrupt system, David is ready to risk it all.