With a new school year comes a new crowd of classmates, and for their final year of junior high, aspiring writer Kotarou Azumi and track team member Akane Mizuno end up in the same class. Though initially complete strangers, a few chance encounters stir an innocent desire within their hearts. A yearning gaze, a fluttering heart—the hallmarks of young love slip into their lives as fate brings their paths to a cross. However, though love is patient and love is kind, Kotarou and Akane discover it is not always straightforward. Despite the comfort they find in each other's company, heartache and anxiety come hand in hand with pursuing the feelings in their hearts. With the uncertainty of how the other truly feels as well as the competing affections of those around them, the road ahead is unclear. Even so, under the shining light of a beautiful full moon, Kotarou gathers his courage to ask Akane a single question, one that forever changes their quiet relationship.

Kimito Kagurazaka is a commoner with a fetish for men's muscles—or at least that's the lie he must keep telling if he wants to keep himself out of trouble at the elite all-girls school, Seikain Academy. Kidnapped by the school under the assumption that he prefers men, Kimito is made to be their commoner sample, exposing the girls to both commoner and man so that the transition to the world after school is not jarring. Threatened with castration should his sexual preferences not match the school's assumptions, Kimito keeps up the facade to protect his manhood. But there are eccentric individuals around every corner who begin to make Kimito's life even more difficult. Among them are Aika Tenkuubashi, a social outcast who blurts out whatever comes to mind; Hakua Shiodome, a young genius; Karen Jinryou, the daughter of samurai who is obsessed with defeating Kimito; and Reiko Arisugawa, the perfect student who has delusions of marrying Kimito. Along with the commoner himself, these four girls make up the Commoner Club, which attempts to teach the girls more about life outside the school, while Kimito gradually learns about the odd girls surrounding him.

Shy, reserved, and small-statured, Deimon High School student Sena Kobayakawa is the perfect target for bullies. However, as a result of running errands throughout his life, Sena has become agile and developed a skill for avoiding crowds of people. After the cunning Youichi Hiruma—captain of the Deimon Devil Bats football team—witnesses Sena's rapid legs in motion, he coerces the timid boy into joining his squad. As Hiruma wants to conceal Sena's identity from other clubs, Sena is forced to hide under the visored helmet of Eyeshield 21, a mysterious running back wearing the number 21 jersey. The legendary Eyeshield 21 can supposedly run at the speed of light and has achieved remarkable feats in the United States during his time at the Notre Dame College. Accustomed to avoiding his problems in the past, Sena's specialty might just help him become the new secret weapon of the Deimon Devil Bats. As he interacts with his teammates, Sena gradually gains more self-confidence and forges valuable bonds along the way.

Like the R Season, Sailor Stars is divided into two parts: The first part resolves some conflicts from the SuperS season, and sees the return of the Outer Senshi, Haruka, Michiru, Setsuna, and Hotaru (now reborn as a child). In the second part Usagi bids farewell to Mamoru, who is going to America to study. At the same time, the Three Lights apper, an idol trio consisting of three boys, Seiya, Taiki, and Yaten. The new enemy is Galaxia, a woman who desires to rule the entire galaxy by collecting the Star Seeds of humans. Three new Senshi appear, the Sailor Starlights, who have their own reasons to stop Galaxia, but without Sailor Moon's help.