Nichijou primarily focuses on the daily antics of a trio of childhood friends—high school girls Mio Naganohara, Yuuko Aioi and Mai Minakami—whose stories soon intertwine with the young genius Hakase Shinonome, her robot caretaker Nano, and their talking cat Sakamoto. With every passing day, the lives of these six, as well as of the many people around them, experience both the calms of normal life and the insanity of the absurd. Walking to school, being bitten by a talking crow, spending time with friends, and watching the principal suplex a deer: they are all in a day's work in the extraordinary everyday lives of those in Nichijou.

While the perfect getaway for most girls her age might be a fancy vacation with their loved ones, Rin Shima's ideal way of spending her days off is camping alone at the base of Mount Fuji. From pitching her tent to gathering firewood, she has always done everything by herself, and has no plans of leaving her little solitary world. However, what starts off as one of Rin's usual camping sessions somehow ends up as a surprise get-together for two when the lost Nadeshiko Kagamihara is forced to take refuge at her campsite. Originally intending to see the picturesque view of Mount Fuji for herself, Nadeshiko's plans are disrupted when she ends up falling asleep partway to her destination. Alone and with no other choice, she seeks help from the only other person nearby. Despite their hasty introductions, the two girls nevertheless enjoy the chilly night together, eating ramen and conversing while the campfire keeps them warm. And even after Nadeshiko's sister finally picks her up later that night, both girls silently ponder the possibility of another camping trip together.

Salaryman Tsuyoshi Mukouda is accidentally summoned as a hero to the Kingdom of Reijseger in another world to help defend against their enemies. Wary of the royal family's true intentions, Mukouda is able to talk his way out of the situation due to his non-combat skill, Online Supermarket, which is deemed useless. However, this power proves to be anything but useless. With this ability, Mukouda is able to cheaply purchase food products and utensils from Japan—most of which are considered luxuries in this world. As Mukouda cooks up a storm using his ability, he catches the eye of the fearsome mythical wolf Fel. The legendary beast swiftly negotiates a contract to become Mukouda's familiar, unable to resist the delicious dishes. With Fel by his side, Mukouda travels the world, earning his keep as an adventurer and merchant all the while enjoying delectable meals.

Having spent Christmas camping with her new friends, Rin Shima embarks on a solo-camping trip to see the New Year sunrise by the sea. All goes according to plan until unforeseen weather blocks the roads back home, making a return trip impossible. Rin, who is now stranded for a few days, is invited by Nadeshiko Kagamihara to stay at her grandmother's house. What is supposed to be a two-day trip becomes an extended period of sightseeing and new experiences for Rin, and she encounters some new and old faces along the way. Yuru Camp△ Season 2 continues the story of Rin, Nadeshiko, and their friends as they further explore the joys of camping.