As Kobayashi sets off for another day at work, she opens her apartment door only to be met by an unusually frightening sight—the head of a dragon, staring at her from across the balcony. The dragon immediately transforms into a cute, busty, and energetic young girl dressed in a maid outfit, introducing herself as Tooru. It turns out that the stoic programmer had come across the dragon the previous night on a drunken excursion to the mountains, and since the mythical beast had nowhere else to go, she had offered the creature a place to stay in her home. Thus, Tooru had arrived to cash in on the offer, ready to repay her savior's kindness by working as her personal maidservant. Though deeply regretful of her words and hesitant to follow through on her promise, a mix of guilt and Tooru's incredible dragon abilities convinces Kobayashi to take the girl in. Despite being extremely efficient at her job, the maid's unorthodox methods of housekeeping often end up horrifying Kobayashi and at times bring more trouble than help. Furthermore, the circumstances behind the dragon's arrival on Earth seem to be much more complicated than at first glance, as Tooru bears some heavy emotions and painful memories. To top it all off, Tooru's presence ends up attracting several other mythical beings to her new home, bringing in a host of eccentric personalities. Although Kobayashi makes her best effort to handle the crazy situation that she has found herself in, nothing has prepared her for this new life with a dragon maid.

A fresh high school year always means much to come, and one of those things is joining a club. Being in a dilemma about which club to join, Yui Hirasawa stumbles upon and applies for the Light Music Club, which she misinterprets to be about playing simple instruments, such as castanets. Unable to play an instrument, she decides to visit to apologize and quit. Meanwhile, the Light Music Club faces disbandment due to a lack of members. This causes the club members to offer anything, from food to slacking off during club time, in order to convince Yui to join. Despite their efforts, Yui insists on leaving due to her lack of musical experience. As a last resort, they play a piece for Yui, which sparks her fiery passion and finally convinces her to join the club. From then onward, it is just plain messing around with bits and pieces of practice. The members of the Light Music Club are ready to make their time together a delightful one!

Hitohito Tadano is an ordinary boy who heads into his first day of high school with a clear plan: to avoid trouble and do his best to blend in with others. Unfortunately, he fails right away when he takes the seat beside the school's madonna—Shouko Komi. His peers now recognize him as someone to eliminate for a chance to sit next to the most beautiful girl in class. Gorgeous and graceful with long, dark hair, Komi is universally adored and immensely popular despite her mysterious persona. However, unbeknownst to everyone, she has crippling anxiety and a communication disorder which prevents her from wholeheartedly socializing with her classmates. When left alone in the classroom, a chain of events forces Komi to interact with Tadano through writing on the blackboard, as if in a one-way conversation. Being the first person to realize she cannot communicate properly, Tadano picks up the chalk and begins to write as well. He eventually discovers that Komi's goal is to make one hundred friends during her time in high school. To this end, he decides to lend her a helping hand, thus also becoming her first-ever friend.

When Kodaka Hasegawa finds out that he will be transferring to a new school, he is determined to make a positive impression, and maybe even some friends. However, Kodaka discovers he is out of luck when he immediately gets labeled as a violent delinquent due to his blond hair and intimidating expression. Although a month has passed, Kodaka is still alone thanks to his notorious reputation. However, his life begins to change when he finds fellow loner Yozora Mikazuki talking to her imaginary friend in an empty classroom. After sharing stories of their lonely high school life, Kodaka and Yozora decide to overcome the difficulties of making friends together by starting the Neighbor's Club. Created for people who don't have friends, daily activities involve learning social skills and how to fit in, which will hopefully allow them to make friends. Joined by the eroge-loving Sena Kashiwazaki, and other eccentric outcasts, Kodaka may finally have managed to find people he can call friends, in this club filled with hilarious oddballs.