Crime is timeless. By the year 2071, humanity has expanded across the galaxy, filling the surface of other planets with settlements like those on Earth. These new societies are plagued by murder, drug use, and theft, and intergalactic outlaws are hunted by a growing number of tough bounty hunters. Spike Spiegel and Jet Black pursue criminals throughout space to make a humble living. Beneath his goofy and aloof demeanor, Spike is haunted by the weight of his violent past. Meanwhile, Jet manages his own troubled memories while taking care of Spike and the Bebop, their ship. The duo is joined by the beautiful con artist Faye Valentine, odd child Edward Wong Hau Pepelu Tivrusky IV, and Ein, a bioengineered Welsh Corgi. While developing bonds and working to catch a colorful cast of criminals, the Bebop crew's lives are disrupted by a menace from Spike's past. As a rival's maniacal plot continues to unravel, Spike must choose between life with his newfound family or revenge for his old wounds.

Justice, and the enforcement of it, has changed. In the 22nd century, Japan enforces the Sibyl System, an objective means of determining the threat level of each citizen by examining their mental state for signs of criminal intent, known as their Psycho-Pass. Inspectors uphold the law by subjugating, often with lethal force, anyone harboring the slightest ill-will; alongside them are Enforcers, jaded Inspectors that have become latent criminals, granted relative freedom in exchange for carrying out the Inspectors' dirty work. Into this world steps Akane Tsunemori, a young woman with an honest desire to uphold justice. However, as she works alongside veteran Enforcer Shinya Kougami, she soon learns that the Sibyl System's judgments are not as perfect as her fellow Inspectors assume. With everything she has known turned on its head, Akane wrestles with the question of what justice truly is, and whether it can be upheld through the use of a system that may already be corrupt.

Dreams are doomed to die in Night City, a futuristic Californian metropolis. As a teenager living in the city's slums, David Martinez is trying to fulfill his mother's lifelong wish for him to reach the top of Arasaka, the world's leading security corporation. To this end, he attends the prestigious Arasaka Academy while his mother works tirelessly to keep their family afloat. When an incident with a street gang leaves David's life in tatters, he stumbles upon Sandevistan cyberware—a prosthetic that grants its wearer superhuman speed. Fueled by rage, David implants the device in his back, using it to exact revenge on one of his tormentors. This gets him expelled from the academy, shattering his hopes of ever making his mother proud. After witnessing David's newfound abilities, the beautiful data thief Lucyna Lucy Kushinada offers to team up with him, handing him a ticket to salvation. However, associating with Lucy introduces David to the world of Edgerunners—cyborg criminals who will break any law for money. Edgerunners often lose their lives, if the cyberware does not break their minds first; but in his fight for survival inside a corrupt system, David is ready to risk it all.

Japan, 1988. An explosion caused by a young boy with psychic powers tears through the city of Tokyo and ignites the fuse that leads to World War III. In order to prevent any further destruction, he is captured and taken into custody, never to be heard from again. Now, in the year 2019, a restored version of the city known as Neo-Tokyo—an area rife with gang violence and terrorism against the current government—stands in its place. Here, Shoutarou Kaneda leads the Capsules, a group of misfits known for riding large, custom motorcycles and being in constant conflict with their rivals the Clowns. During one of these battles, Shoutarou's best friend Tetsuo Shima is caught up in an accident with an esper who finds himself in the streets of Tokyo after escaping confinement from a government institution. Through this encounter, Tetsuo begins to develop his own mysterious abilities, as the government seeks to quarantine this latest psychic in a desperate attempt to prevent him from unleashing the destructive power that could once again bring the city to its knees.