After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

Barely surviving in a barrel after passing through a terrible whirlpool at sea, carefree Monkey D. Luffy ends up aboard a ship under attack by fearsome pirates. Despite being a naive-looking teenager, he is not to be underestimated. Unmatched in battle, Luffy is a pirate himself who resolutely pursues the coveted One Piece treasure and the King of the Pirates title that comes with it. The late King of the Pirates, Gol D. Roger, stirred up the world before his death by disclosing the whereabouts of his hoard of riches and daring everyone to obtain it. Ever since then, countless powerful pirates have sailed dangerous seas for the prized One Piece only to never return. Although Luffy lacks a crew and a proper ship, he is endowed with a superhuman ability and an unbreakable spirit that make him not only a formidable adversary but also an inspiration to many. As he faces numerous challenges with a big smile on his face, Luffy gathers one-of-a-kind companions to join him in his ambitious endeavor, together embracing perils and wonders on their once-in-a-lifetime adventure.

Simon and Kamina were born and raised in a deep, underground village, hidden from the fabled surface. Kamina is a free-spirited loose cannon bent on making a name for himself, while Simon is a timid young boy with no real aspirations. One day while excavating the earth, Simon stumbles upon a mysterious object that turns out to be the ignition key to an ancient artifact of war, which the duo dubs Lagann. Using their new weapon, Simon and Kamina fend off a surprise attack from the surface with the help of Yoko Littner, a hot-blooded redhead wielding a massive gun who wanders the world above. In the aftermath of the battle, the sky is now in plain view, prompting Simon and Kamina to set off on a journey alongside Yoko to explore the wastelands of the surface. Soon, they join the fight against the Beastmen, humanoid creatures that terrorize the remnants of humanity in powerful robots called Gunmen. Although they face some challenges and setbacks, the trio bravely fights these new enemies alongside other survivors to reclaim the surface, while slowly unraveling a galaxy-sized mystery.

Years after an ancient evil was salvaged from the depths of the sea, Joutarou Kuujou sits peacefully within a Japanese jail cell. He's committed no crime yet demands he not be released, believing he's been possessed by an evil spirit capable of harming those around him. Concerned for her son, Holy Kuujou asks her father, Joseph Joestar, to convince Joutarou to leave the prison. Joseph informs his grandson that the evil spirit is in fact something called a Stand, the physical manifestation of one's fighting spirit which can adopt a variety of deadly forms. After a fiery brawl with Joseph's friend Muhammad Avdol, Joutarou is forced out of his cell and begins learning how to control the power of his Stand. However, when a Stand awakens within Holy and threatens to consume her in 50 days, Joutarou, his grandfather, and their allies must seek out and destroy the immortal vampire responsible for her condition. They must travel halfway across the world to Cairo, Egypt and along the way, do battle with ferocious Stand users set on thwarting them. If Joutarou and his allies fail in their mission, humanity is destined for a grim fate.