After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

As a wild youth, elementary school student Shouya Ishida sought to beat boredom in the cruelest ways. When the deaf Shouko Nishimiya transfers into his class, Shouya and the rest of his class thoughtlessly bully her for fun. However, when her mother notifies the school, he is singled out and blamed for everything done to her. With Shouko transferring out of the school, Shouya is left at the mercy of his classmates. He is heartlessly ostracized all throughout elementary and middle school, while teachers turn a blind eye. Now in his third year of high school, Shouya is still plagued by his wrongdoings as a young boy. Sincerely regretting his past actions, he sets out on a journey of redemption: to meet Shouko once more and make amends. Koe no Katachi tells the heartwarming tale of Shouya's reunion with Shouko and his honest attempts to redeem himself, all while being continually haunted by the shadows of his past.

In the year 2010, the Holy Empire of Britannia is establishing itself as a dominant military nation, starting with the conquest of Japan. Renamed to Area 11 after its swift defeat, Japan has seen significant resistance against these tyrants in an attempt to regain independence. Lelouch Lamperouge, a Britannian student, unfortunately finds himself caught in a crossfire between the Britannian and the Area 11 rebel armed forces. He is able to escape, however, thanks to the timely appearance of a mysterious girl named C.C., who bestows upon him Geass, the Power of Kings. Realizing the vast potential of his newfound power of absolute obedience, Lelouch embarks upon a perilous journey as the masked vigilante known as Zero, leading a merciless onslaught against Britannia in order to get revenge once and for all.

Kousei Arima is a child prodigy known as the Human Metronome for playing the piano with precision and perfection. Guided by a strict mother and rigorous training, Kousei dominates every competition he enters, earning the admiration of his musical peers and praise from audiences. When his mother suddenly passes away, the subsequent trauma makes him unable to hear the sound of a piano, and he never takes the stage thereafter. Nowadays, Kousei lives a quiet and unassuming life as a junior high school student alongside his friends Tsubaki Sawabe and Ryouta Watari. While struggling to get over his mother's death, he continues to cling to music. His monochrome life turns upside down the day he encounters the eccentric violinist Kaori Miyazono, who thrusts him back into the spotlight as her accompanist. Through a little lie, these two young musicians grow closer together as Kaori tries to fill Kousei's world with color.