Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

Eighth-grader Shigeo Mob Kageyama has tapped into his inner wellspring of psychic prowess at a young age. But the power quickly proves to be a liability when he realizes the potential danger in his skills. Choosing to suppress his power, Mob's only present use for his ability is to impress his longtime crush, Tsubomi, who soon grows bored of the same tricks. In order to effectuate control on his skills, Mob enlists himself under the wing of Arataka Reigen, a con artist claiming to be a psychic, who exploits Mob's powers for pocket change. Now, exorcising evil spirits on command has become a part of Mob's daily, monotonous life. However, the psychic energy he exerts is barely the tip of the iceberg; if his vast potential and unrestrained emotions run berserk, a cataclysmic event that would render him completely unrecognizable will be triggered. The progression toward Mob's explosion is rising and attempting to stop it is futile.

In times of need, if you look in the right place, you just may see a strange telephone number scrawled in red. If you call this number, you will hear a young man introduce himself as the Yato God. Yato is a minor deity and a self-proclaimed Delivery God, who dreams of having millions of worshippers. Without a single shrine dedicated to his name, however, his goals are far from being realized. He spends his days doing odd jobs for five yen apiece, until his weapon partner becomes fed up with her useless master and deserts him. Just as things seem to be looking grim for the god, his fortune changes when a middle school girl, Hiyori Iki, supposedly saves Yato from a car accident, taking the hit for him. Remarkably, she survives, but the event has caused her soul to become loose and hence able to leave her body. Hiyori demands that Yato return her to normal, but upon learning that he needs a new partner to do so, reluctantly agrees to help him find one. And with Hiyori's help, Yato's luck may finally be turning around.

Humans and demons are two sides of the same coin, as are Assiah and Gehenna, their respective worlds. The only way to travel between the realms is by the means of possession, like in ghost stories. However, Satan, the ruler of Gehenna, cannot find a suitable host to possess and therefore, remains imprisoned in his world. In a desperate attempt to conquer Assiah, he sends his son instead, intending for him to eventually grow into a vessel capable of possession by the demon king. Ao no Exorcist follows Rin Okumura who appears to be an ordinary, somewhat troublesome teenager—that is until one day he is ambushed by demons. His world turns upside down when he discovers that he is in fact the very son of Satan and that his demon father wishes for him to return so they can conquer Assiah together. Not wanting to join the king of Gehenna, Rin decides to begin training to become an exorcist so that he can fight to defend Assiah alongside his brother Yukio.