Sixteen sentient races inhabit Disboard, a world overseen by Tet, the One True God. The lowest of the sixteen—Imanity—consists of humans, a race with no affinity for magic. In a place where everything is decided through simple games, humankind seems to have no way out of their predicament—but the arrival of two outsiders poses a change. On Earth, stepsiblings Sora and Shiro are two inseparable shut-ins who dominate various online games under the username Blank. While notorious on the internet, the pair believe that life is merely another dull game. However, after responding to a message from an unknown user, they are suddenly transported to Disboard. The mysterious sender turns out to be Tet, who informs them about the world's absolute rules. After Tet leaves, Sora and Shiro begin their search for more information and a place to stay, taking them to Elkia—Imanity's only remaining kingdom. There, the duo encounters Stephanie Dola, an emotional girl vying for the kingdom's sovereignty. In desperation, she attempts to regain her father's throne, but her foolhardiness makes her goal unachievable. Inspired by the girl's motivation and passion, Sora and Shiro decide to aid Stephanie in getting Elkia back on its feet, ultimately aiming to become the new rulers of the enigmatic realm.

In the year 2010, the Holy Empire of Britannia is establishing itself as a dominant military nation, starting with the conquest of Japan. Renamed to Area 11 after its swift defeat, Japan has seen significant resistance against these tyrants in an attempt to regain independence. Lelouch Lamperouge, a Britannian student, unfortunately finds himself caught in a crossfire between the Britannian and the Area 11 rebel armed forces. He is able to escape, however, thanks to the timely appearance of a mysterious girl named C.C., who bestows upon him Geass, the Power of Kings. Realizing the vast potential of his newfound power of absolute obedience, Lelouch embarks upon a perilous journey as the masked vigilante known as Zero, leading a merciless onslaught against Britannia in order to get revenge once and for all.

Crime is timeless. By the year 2071, humanity has expanded across the galaxy, filling the surface of other planets with settlements like those on Earth. These new societies are plagued by murder, drug use, and theft, and intergalactic outlaws are hunted by a growing number of tough bounty hunters. Spike Spiegel and Jet Black pursue criminals throughout space to make a humble living. Beneath his goofy and aloof demeanor, Spike is haunted by the weight of his violent past. Meanwhile, Jet manages his own troubled memories while taking care of Spike and the Bebop, their ship. The duo is joined by the beautiful con artist Faye Valentine, odd child Edward Wong Hau Pepelu Tivrusky IV, and Ein, a bioengineered Welsh Corgi. While developing bonds and working to catch a colorful cast of criminals, the Bebop crew's lives are disrupted by a menace from Spike's past. As a rival's maniacal plot continues to unravel, Spike must choose between life with his newfound family or revenge for his old wounds.

Unlike many schools, attending Hyakkaou Private Academy prepares students for their time in the real world. Since many of the students are the children of the richest people in the world, the academy has its quirks that separate it from all the others. By day, it is a normal school, educating its pupils in history, languages, and the like. But at night, it turns into a gambling den, educating them in the art of dealing with money and manipulating people. Money is power; those who come out on top in the games stand at the top of the school. Yumeko Jabami, a seemingly naive and beautiful transfer student, is ready to try her hand at Hyakkaou's special curriculum. Unlike the rest, she doesn't play to win, but for the thrill of the gamble, and her borderline insane way of gambling might just bring too many new cards to the table.