When Keyaru acquired his powers as a Hero who specialized in healing all injuries regardless of severity, it seemed that he would walk the path to a great future. But what awaited him instead was great agony; he was subjected to years of seemingly endless hellish torture and abuse. Keyaru's healing skills allowed him to secretly collect the memories and abilities of those he treated, gradually making him stronger than anyone else. But by the time he reached his full potential, it was far too late—he had already lost everything. Determined to put his life back on track, Keyaru decided to unleash a powerful healing spell that rewound the entire world back to the time before he began to suffer his horrible fate. Equipped with the anguish of his past, he vows to redo everything in order to fulfill a new purpose—to exact revenge upon those who have wronged him.

As far as it goes, many boys, especially in their teenage years, want to have a girlfriend. Keiki Kiryuu is no exception. One eventful afternoon, his days of yearning for a lover seem to come to an end when he receives a love letter from an anonymous sender—along with a pair of white panties. To determine the identity of his secret admirer, referred to as Cinderella, he proceeds to investigate several possible candidates including his senior Sayuki Tokihara, his underclassman Yuika Koga, and his classmate Mao Nanjou. However, as Keiki seeks to uncover who this mystery girl might be, he comes to know about the perverted fetishes hidden behind each candidate's innocent exteriors...

Reito Mizuhara is a medical student at the National Advanced Medical School in Tokyo who contracts a rare, lethal disease called cellular sclerosis. In order to be treated, he is put into cryogenic sleep for five years. Upon awakening, he learns that a year into his slumber, a worldwide pandemic broke out, caused by the novel Male Killer (MK) virus which exclusively afflicts males and has killed all other men on Earth. Fortunately, Reito and four other men were spared during their cryosleep and are now immune to the virus. As the only men left in the world, they are thus tasked with mating with as many women as possible to repopulate the planet. However, Reito is committed to his childhood friend and sole love interest, Elisa Tachibana—only to learn that she went missing three years ago. While the other male survivors adapt accordingly to this new world, Reito instead chooses to pursue Elisa, fight never-ending temptation, and investigate this mysterious virus.

All his life, Shiki has been surrounded by machines. At Granbell Kingdom, a long-abandoned amusement park, he is the only one of his kind around. That is, until Rebecca Bluegarden and her feline companion Happy arrive, unaware that they are Granbell's first visitors in one hundred years. Their goal is to make fun videos for their B-Cube channel, but what they find instead is a friend in the socially awkward Shiki. When Granbell becomes too dangerous for the three of them, they set off on an adventure through the Sakura Cosmos. They hope to make more interesting videos and even find the elusive goddess Mother, while Shiki wants to make more friends, spurred on by the words of his late grandfather. Of course, the journey will not be easy, as no one has seen Mother before, but Shiki is determined to reach his goal and explore the boundless reaches of space together with his new friends.