On the surface, the thought of Kyouko Hori and Izumi Miyamura getting along would be the last thing in people's minds. After all, Hori has a perfect combination of beauty and brains, while Miyamura appears meek and distant to his fellow classmates. However, a fateful meeting between the two lays both of their hidden selves bare. Even though she is popular at school, Hori has little time to socialize with her friends due to housework. On the other hand, Miyamura lives under the noses of his peers, his body bearing secret tattoos and piercings that make him look like a gentle delinquent. Having opposite personalities yet sharing odd similarities, the two quickly become friends and often spend time together in Hori's home. As they both emerge from their shells, they share with each other a side of themselves concealed from the outside world.

Edo is a city that was home to the vigor and ambition of samurai across the country. However, following feudal Japan's surrender to powerful aliens known as the Amanto, those aspirations now seem unachievable. With the once-influential shogunate rebuilt as a puppet government, a new law is passed that promptly prohibits all swords in public. Enter Gintoki Sakata, an eccentric silver-haired man who always carries around a wooden sword and maintains his stature as a samurai despite the ban. As the founder of Yorozuya, a small business for odd jobs, Gintoki often embarks on endeavors to help other people—though usually in rather strange and unforeseen ways. Assisted by Shinpachi Shimura, a boy with glasses supposedly learning the way of the samurai; Kagura, a tomboyish girl with superhuman strength and an endless appetite; and Sadaharu, their giant pet dog who loves biting on people's heads, the Yorozuya encounter anything from alien royalty to scuffles with local gangs in the ever-changing world of Edo.

Wishing to be independent, 16-year-old Maika Sakuranomiya is desperate to nail down a part-time job so that she can afford to study abroad. Unfortunately, her applications are constantly rejected due to the menacing look she unintentionally makes whenever she smiles, despite her otherwise cheerful disposition. After yet another failed interview, she chances upon Café Stile, a coffee shop where the servers interact with the customers while roleplaying distinctive characteristics. The Italian store manager, Dino, becomes infatuated with Maika's cuteness at first sight, and offers her a job as a waitress with a sadistic nature. Coupled with her inherent clumsiness, she successfully manages to serve a pair of masochistic customers in accordance with her new, ruthless persona. Alongside Kaho Hinata as the tsundere and Mafuyu Hoshikawa as the younger sister, Maika decides to make the most out of her unique quirk and cements her position in the cafe with merciless cruelty!

When Keyaru acquired his powers as a Hero who specialized in healing all injuries regardless of severity, it seemed that he would walk the path to a great future. But what awaited him instead was great agony; he was subjected to years of seemingly endless hellish torture and abuse. Keyaru's healing skills allowed him to secretly collect the memories and abilities of those he treated, gradually making him stronger than anyone else. But by the time he reached his full potential, it was far too late—he had already lost everything. Determined to put his life back on track, Keyaru decided to unleash a powerful healing spell that rewound the entire world back to the time before he began to suffer his horrible fate. Equipped with the anguish of his past, he vows to redo everything in order to fulfill a new purpose—to exact revenge upon those who have wronged him.