After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

Eccentric scientist Rintarou Okabe has a never-ending thirst for scientific exploration. Together with his ditzy but well-meaning friend Mayuri Shiina and his roommate Itaru Hashida, Okabe founds the Future Gadget Laboratory in the hopes of creating technological innovations that baffle the human psyche. Despite claims of grandeur, the only notable gadget the trio have created is a microwave that has the mystifying power to turn bananas into green goo. However, when Okabe attends a conference on time travel, he experiences a series of strange events that lead him to believe that there is more to the Phone Microwave gadget than meets the eye. Apparently able to send text messages into the past using the microwave, Okabe dabbles further with the time machine, attracting the ire and attention of the mysterious organization SERN. Due to the novel discovery, Okabe and his friends find themselves in an ever-present danger. As he works to mitigate the damage his invention has caused to the timeline, Okabe fights a battle to not only save his loved ones but also to preserve his degrading sanity.

Ryuuji Takasu is a gentle high school student with a love for housework; but in contrast to his kind nature, he has an intimidating face that often gets him labeled as a delinquent. On the other hand is Taiga Aisaka, a small, doll-like student, who is anything but a cute and fragile girl. Equipped with a wooden katana and feisty personality, Taiga is known throughout the school as the Palmtop Tiger. One day, an embarrassing mistake causes the two students to cross paths. Ryuuji discovers that Taiga actually has a sweet side: she has a crush on the popular vice president, Yuusaku Kitamura, who happens to be his best friend. But things only get crazier when Ryuuji reveals that he has a crush on Minori Kushieda—Taiga's best friend! Toradora! is a romantic comedy that follows this odd duo as they embark on a quest to help each other with their respective crushes, forming an unlikely alliance in the process.

Night Raid is the covert assassination branch of the Revolutionary Army, an uprising assembled to overthrow Prime Minister Honest, whose avarice and greed for power has led him to take advantage of the child emperor's inexperience. Without a strong and benevolent leader, the rest of the nation is left to drown in poverty, strife, and ruin. Though the Night Raid members are all experienced killers, they understand that taking lives is far from commendable and that they will likely face retribution as they mercilessly eliminate anyone who stands in the revolution's way. This merry band of assassins' newest member is Tatsumi, a naïve boy from a remote village who had embarked on a journey to help his impoverished hometown and was won over by not only Night Raid's ideals, but also their resolve. Akame ga Kill! follows Tatsumi as he fights the Empire and comes face-to-face with powerful weapons, enemy assassins, challenges to his own morals and values, and ultimately, what it truly means to be an assassin with a cause.