This is the story of Natsunosuke Honda, a pro baseball player—a relief pitcher who has been playing pro in a team called Spiders for 8 years. The team operates as a highly-stratified society, where the player's performance determines his annual salary. Natsunosuke is one of the highest paid players in the game. He measures how good players are by how much money they make, and he intends to be on top and stay there, and as such is always looking for players to challenge and does everything to insure that he is better than they are. (Source: MAL News)

The war on terror exploded, literally, the day Sarajevo was destroyed by a homemade nuclear device. The leading democracies transformed into total surveillance states, and the developing world has drowned under a wave of genocides. The mysterious American John Paul seems to be behind the collapse of the world system, and it's up to intelligence agent Clavis Shepherd to track John Paul across the wreckage of civilizations and to find the true heart of darkness—a genocidal organ. (Source: Viz Media)

Owing to an increasing debt, Kaiji Itou ends up resuming his old lifestyle. One day, while walking on the street, he stumbles upon Yuuji Endou, who is hunting Kaiji due to the money he owes to the Teiai Group. Unaware of this, Kaiji eagerly follows Endou, hoping for a chance to participate in another gamble, but soon finds out the loan shark's real intentions when he is kidnapped. Given that Kaiji is unable to pay off his huge debt, the Teiai Group instead sends him to work in an underground labor camp. He is told that he will have to live in this hell for 15 years, alongside other debtors, until he can earn his freedom. His only hope to put an early end to this nightmare is by saving enough money to be able to go back to the surface for a single day. Once he is there, he plans to obtain the remaining money needed to settle his account by making a high-stakes wager. However, as many temptations threaten his scarce income, Kaiji may have to resort to gambling sooner than he had expected.

Defense attorney Ryuuichi Naruhodou is still hard at work defending the falsely accused with his knack for last-minute turnabouts. With his trusty assistant and medium-in-training Mayoi Ayasato in tow, Ryuuichi's fame as a champion for the innocent steadily grows. But this newfound success attracts the attention of the coffee-loving, masked Godot⁠—a mysterious rookie prosecutor who bears an inexplicable grudge against Ryuuichi. With the help of their allies, Ryuuichi and Mayoi take this new challenger head-on and search for the reason behind his appearance. But before long, the first two cases from the career of Mayoi's late sister Chihiro Ayasato become critical to solving a fantastical murder mystery, continuing the bloody saga of the tumultuous Ayasato clan. Will Ryuuichi once again be able to overcome the odds and find the truths hidden within the web of lies?