Taking place in a very distant in future, the adventure begins when a boy meets a certain girl. The Pan Galaxy Republic has declined and so have many empires. This resulted to people in the galaxy being scattered. Living in the peaceful side of their world, Banjou, who picks up trashes at the spherical wall met a girl, frozen, in a broken spaceship. There are bad guys who chase her, and thus, the quiet galaxy suddenly became lively. Little did he know that the frozen girl is Goza 168th, the key to decide the destiny of the whole universe. Overcoming hardship, the two embarks on a trip to make the Galaxy Republic alive again. It may be a difficult challenge, but it's alright, let's progress slowly! A comedy of irresponsible galaxy trip begins! (Source: MAL News)

The entire countryside comes to a halt midday to witness a rare solar eclipse that is rumored to allow the average person to see Mushi. Unable to avert their gaze, the air is full of awe and wonder—but those who know the Mushi are preparing for the eclipse's aftermath. Based on a prediction from Tanyuu Karibusa, the cursed recorder, Mushishi Ginko finds himself in a very unlucky farming village. Immediately following the solar eclipse, a strange black cloud begins to gather in the sky and blocks the sun once more. Suspecting it to be the work of a Mushi known as Hihami, Ginko seeks to liberate the village from perpetual darkness. However, it seems that not all of the villagers are eager to return to the light.

Mysterious, unknowable creatures alien to the laws of nature—known only to some and feared by others—Mushi lie behind many of life's strange phenomena. Long ago, a Mushi of terrifying power threatened to extinguish all life. The Minai clan of Mushishi were born from those who stopped this malevolent force, their members bound by duty to serve as retainers to the Karibusa family, within whom the Mushi remains sealed. The Mushishi Ginko is given a job request from Tanyuu Karibusa: oversee the work of the head of the Minai clan, Kumado Minai, in investigating an abandoned village where dead wood and even houses spring back to life as flourishing plants. Though the Minai clan are oddly ruthless among Mushishi, even more peculiar is their widespread dull character, with little appreciation for beauty or sentiment. Tanyuu believes there is more to this trend than meets the eye. Ginko aims to answer her curiosity as he follows Kumado into a Path of Thorns, a place where Mushi flow from their own strange sources into the world of the living. Rare and deadly varieties of Mushi lurk in these depths, along with the secret nature of the Minai clan's resolve to their ancient task.

The first episode, Musha, Knight, Commando: SD Gundam Emergency Sortie, features the three Gundams and a young girl named Riplin joining together to fight evil. The second episode, Dawn of Papal, Episode 103: Suginamu's Bride, stars Artesia in a fantasy-themed adventure.