Sixteen sentient races inhabit Disboard, a world overseen by Tet, the One True God. The lowest of the sixteen—Imanity—consists of humans, a race with no affinity for magic. In a place where everything is decided through simple games, humankind seems to have no way out of their predicament—but the arrival of two outsiders poses a change. On Earth, stepsiblings Sora and Shiro are two inseparable shut-ins who dominate various online games under the username Blank. While notorious on the internet, the pair believe that life is merely another dull game. However, after responding to a message from an unknown user, they are suddenly transported to Disboard. The mysterious sender turns out to be Tet, who informs them about the world's absolute rules. After Tet leaves, Sora and Shiro begin their search for more information and a place to stay, taking them to Elkia—Imanity's only remaining kingdom. There, the duo encounters Stephanie Dola, an emotional girl vying for the kingdom's sovereignty. In desperation, she attempts to regain her father's throne, but her foolhardiness makes her goal unachievable. Inspired by the girl's motivation and passion, Sora and Shiro decide to aid Stephanie in getting Elkia back on its feet, ultimately aiming to become the new rulers of the enigmatic realm.

Life in rural Asahigaoka moves at its own pace. Devoid of the pleasures and worries of a bustling metropolis, this small village might seem painfully dull at first glance. However, despite living this far from her hometown of Tokyo, Hotaru Ichijou manages to find a group of friends whom she can spend quality time with. No matter whether it is winter, spring, summer, or fall, they make full use of everything the nature around them has to offer.

Al Wayne's greatest goal is to become the best farmer he can be. With utmost effort, he reaches the apex of his farming skills and earns the title of a first-rate cultivator. Due to this achievement, Al gains a substantial upgrade to his stats which now eclipse even the strength of legendary heroes of old. Soon after discovering his potential, the royal family enlists his help against the rising number of disasters that coincidentally began right as his true power was awakened. Although reluctant, Al concedes that in order to protect his precious fields, he must do his best to keep all threats at bay.

Shinichi Chiaki is quickly making a name for himself as the principal conductor of the revitalized Roux-Marlet Orchestra, and Megumi Nodame Noda has made leaps and bounds as a pianist at the Conservatoire de Paris. However, tensions mount between the two as Nodame feels left behind by Chiaki's growing success and his close friendship with legendary piano prodigy Rui Son. Disregarding her teacher Professor Charles Auclair's advice, Nodame enters another piano competition in an attempt to jumpstart her own performance career. Meanwhile, those around Chiaki and Nodame are at their own crossroads. Rui begins to doubt herself after hearing Nodame's playing and being denied tutelage from Auclair; Maestro Franz von Stresemann faces the reality of his mortality; pianists Yunlong Li and Tatiana Vishneva feverishly prepare for a competition, while the latter also struggles with her growing feelings for oboist and fellow student Yasunori Kuroki. As Chiaki, Nodame, and their friends continue on their respective journeys, they must not only strive to stay true to themselves, but also remember where it all started.