When loner Touka Mimori is summoned to another world alongside his classmates, he obtains the power to inflict status ailments, such as paralysis or poison, on his enemies. Unfortunately for him, skills of this nature are considered useless due to their low success rate, and Touka is thus assigned the title of E-rank hero. Things take a further turn for the worse when Vicius, the goddess who summoned the class, reveals that the lowest-ranked hero will be disposed of so that they do not hinder those with greater talent. Banished to a notoriously dangerous area, Touka comes face-to-face with death after being cornered by a minotaur-like creature. In a desperate attempt to survive, he uses his supposedly worthless skill—only to quickly realize that it works almost every time. Armed with the ability to render the monsters standing in his way completely helpless, Touka resolves to track down the goddess that tossed him aside and exact his revenge.

With a cartload of fur pelts in tow, traveling merchant Kraft Lawrence stops by the village of Pasloe. According to local folklore, centuries ago, one of the villagers made a promise with the wolf deity Holo, who swore to bless Pasloe with bountiful harvests of wheat. Yet, as time passed, such stories became little more than relics of the past. After quickly finishing his business in the village, Lawrence sets out to his next destination. His journey, however, takes an unexpected turn when he discovers a nude, animal-eared girl sleeping among his pelts. Even more surprisingly, the youthful-looking woman claims to be Holo—the wolf of legend. Holo wishes to return to her hometown in the north, and though their first encounter is rocky, she convinces Lawrence to accompany her on her travels. In return, she vows to earn her keep, using her quick wits and lifetime of experience to help her newfound companion in his dealings. As they continue their journey, Lawrence and Holo take advantage of whatever economic opportunities they come across, often landing in situations that put both their business skills and their relationship to the test.

An evil army is leading a ground invasion against Earth, and their Lieutenant Shun Miller is determined to wreak havoc upon the populace. Miller's ruthless reputation strikes fear even into the hearts of his own subordinates, making him the perfect leader of a charge against a city protected by a powerful magical girl, Byakuya Mimori. However, his attack comes to a halt on the day of their first encounter—because he unexpectedly falls in love with Byakuya at first sight! Overcome by Byakuya's adorably delicate innocence, Miller begins to shower her with gifts and kindness. But Miller soon learns that Byakuya's Angel—the cat-like familiar who turned her into a magical girl—has been exploiting and manipulating her all along. This discovery solidifies Miller's resolve to ensure Byakuya goes on to lead a happier life, but as the war continues, they wonder if their blossoming affection can overcome the reality of their differences.

Just as the famous writer Sensei is about to accomplish his life ambition and commit double suicide with his lover Sacchan, he is hit by a truck and transported to another world. Deemed an adventurer by the local priestess Annette, Sensei is given the daunting mission of slaying the demon king. Refusing to play into his new role, Sensei decides his efforts are better served looking for Sacchan in the hope that she is somewhere in this new world. Early on in his journey, Sensei crosses paths with the martial artist Tama and unexpectedly saves her from mortal peril. Grateful for his actions, Tama decides to escort him. The pair are soon joined by Annette who, seduced by the writer's strong personality, has sworn to protect Sensei's life. As the unlikely trio wander the dangerous, monster-infested lands, they soon realize that human beings might be the true threats to the peace of the world—and Sensei might be the only one with the power to stop them.