Edward Elric, a young, brilliant alchemist, has lost much in his twelve-year life: when he and his brother Alphonse try to resurrect their dead mother through the forbidden act of human transmutation, Edward loses his brother as well as two of his limbs. With his supreme alchemy skills, Edward binds Alphonse's soul to a large suit of armor. A year later, Edward, now promoted to the fullmetal alchemist of the state, embarks on a journey with his younger brother to obtain the Philosopher's Stone. The fabled mythical object is rumored to be capable of amplifying an alchemist's abilities by leaps and bounds, thus allowing them to override the fundamental law of alchemy: to gain something, an alchemist must sacrifice something of equal value. Edward hopes to draw into the military's resources to find the fabled stone and restore his and Alphonse's bodies to normal. However, the Elric brothers soon discover that there is more to the legendary stone than meets the eye, as they are led to the epicenter of a far darker battle than they could have ever imagined.

Based on the horror novel by Fujio (A) Fujiko.

Two years ago, Mitsuki Kouyama's friend, Eichi Sakurai, moved to America before she could confess her feelings to him. Though she cannot contact him, they made a promise to fulfill their respective dreams: Mitsuki wants to become a professional singer, and Eichi an astronomer. She hopes that one day her music will reach him across the world with a brilliance like that of the full moon. There is just one catch: Mitsuki suffers from throat cancer, which makes her voice quiet and singing strenuous. Her grandmother, who has a hatred of music, insists that Mitsuki undergo surgery to remove the cancer, but she refuses due to the risk of losing her voice. One day, two shinigami—Meroko Yui and Takuto Kira—appear to tell her that she only has one year left to live. This sudden revelation spurs Mitsuki into action, and she decides that with Meroko and Takuto's help, she will become a professional singer in the time she has left. Full Moon wo Sagashite follows the emotional story of Mitsuki and her shinigami friends as they discover what it means to sing—and ultimately, what it means to live.

After overcoming various tumultuous events, mercenary sergeant Sousuke Sagara of Mithril and Whispered school girl Kaname Chidori return to their normal high school lives. Sousuke continues his efforts to assimilate with the civilian population and manage his mission at the same time, while Kaname attempts to support his endeavors (even though his antics often drive her up a wall). However, as their lives calm, new problems begin to appear. The appearance of an independent terrorist organization known as Amalgam and internal conflicts within Mithril threaten to wreak unity into a series of failures and betrayals. And new, powerful Arm Slave models only worsen the situation when the world's peace is at stake. As Kaname and Sousuke face their own inner battles amidst life-threatening fights, will they be able to make the right choices and change their future?