Following the revelations of the archangel Gabriel, Ente Isla hero Emilia Justina—who lives on Earth under the alias Emi Yusa—starts doubting the validity of her mission to slay the Demon Lord Satan, now reduced to a modest employee of MgRonald's as Sadao Maou. At the same time, Sadao's high school-aged coworker Chiho Sasaki pursues a new dream with hopes to protect not only herself but also her friends. Secretly training with Emi and Suzuno Kamazuki to develop telepathic powers, Chiho's training is cut short when a group of demons abducts her. As angel and demon attacks threaten the fragile peace between the two worlds, Sadao and Emi need to put their troubled past behind them if they want to have a chance to find their new purpose in life.

In a world where death is not permanent, Terakomari Komari Gandesblood has been a self-proclaimed professional shut-in for the past three years. As part of the noble Gandesblood lineage, she once tried to meet the expectations of her family. However, as a vampire who cannot use magic or consume blood, she soon gave up on becoming an imperial general like her ancestors. Unfortunately, a misunderstanding with her father earns her the formidable position of one of the Seven Crimson Lords, the strongest fighters and generals in the Mulnite Empire. Now, Komari must hide her lack of talent from the soldiers she commands, or they may attempt to overthrow her. Working alongside her newly-assigned maid, Villhaze, Komari manages to trick her unit of soldiers into believing she is a ruthless warlord and promises to conquer the world. But as more people come to admire Komari, her life is further threatened as a vampire from her past reappears with every intention to kill her for good.

A recent uptick in civilian riots and crimes has been observed across the country following the conclusion of the second Division Rap Battle. To make matters more chaotic, the individuals perpetrating the crimes have no recollection of the incidents nor any reason to be committing them in the first place. Suspecting these events to be linked to the effect of the Hypnosis Microphones, the governing Party of Words begins investigating the whereabouts of the mastermind behind them. These cases have been more frequent in the six divisions, and their respective leaders are scrambling to find a way to prevent further havoc. But when the culprit pulling the strings threatens their territories with more calamity, the six leaders must put aside their personal differences and work together to stop this mayhem.

Since childhood, 15-year-old Umika Konohoshi has been fascinated by aliens, hoping to one day voyage to outer space and befriend them. Unfortunately, this fixation has caused her peers to label her as odd, intensifying her struggle with severe social anxiety. Nevertheless, Umika's passion for the extraterrestrial persists, and she deeply believes that her true purpose is outside the confines of Earth. On her first day of high school, Umika's wish of meeting an alien seems to have finally come true when she encounters Yuu Akeuchi—a classmate who claims to have crash-landed on Earth with no recollections of her past. Umika tries to seize this opportunity to make friends with Yuu, but her lack of confidence hinders her. Sensing Umika's distress, Yuu suddenly uses a strange power to delve deep into her mind, thus sparking a friendship that may just help Umika reach her dreams.