Nanako is a an inept apprentice nurse to the brilliant young Dr. Kouji. Now for some reason, Nanako is always being targeted by various elements which makes Nanako wonder if she has done anything wrong. But there are certain secrets to Nanako's past that only Dr. Kouji and his family know about.

Departing from their respective hometowns, two young women with identical names are brought together in their pursuit of new beginnings. With their hearts set on going to Tokyo, Nana Komatsu dreams about blissful love, while Nana Osaki aims for a successful music career. The former has a cheerful and friendly nature, but her naivety has steered her romantic life astray until she meets her dependable boyfriend—Shouji Endo. Without letting herself be dismayed by Shouji's decision to study in Tokyo, Nana works hard to earn enough money and follow him there. Meanwhile, her namesake is a solitary punk vocalist whose impassioned romance with her band's bassist, Ren Honjou, comes to a sudden end. Though heartbroken, Nana bravely looks forward and travels to the capital with the ambition of becoming a recognized artist. Shortly after they arrive in Tokyo, the girls cross paths again due to an unexpected coincidence that ultimately leads them to live under the same roof. As they grow closer, the two strive to support one another amid their struggles to forge a future for themselves.

Michi and her family have just moved into the Happiness House, a huge tree with all sorts of little buildings and houses built on and inside of it. Upon exploring what is to be her new bedroom, Michi finds an odd nut-like object. Before long, a strange creature, Nanami-chan, hatches out of it. The two become fast friends. Together, Michi and Nanami-chan learn all kind of new things, and everyday they meet more eccentric residents of the Happiness House. (Source: ANN)

Extra episode of Nagato Yuki-chan no Shoushitsu bundled with the limited edition of the 9th manga volume.