Since childhood, Haruka Kotoura's classmates have seen her as a creepy and monstrous person. This is due to her ability to read other people's minds—the same ability that drove her parents away, leaving her alone with her grandfather. As a result, she has grown accustomed to the bitter treatment by the people around her, becoming completely cold and unsociable to others. However, everything starts to change when Haruka transfers to a new school. While most are off put by her as usual, she meets Yoshihisa Manabe, who finds her power astonishing. Yoshihisa then proceeds to befriend Haruka, promising to never leave her no matter what happens. Haruka's new experiences of social belonging thus begin, meeting new friends and learning to open herself along the way.

Aikawa Ayumu was revived as a zombie by the cute necromancer Eucliwood Hellscythe. After the zany, madcap adventures in the first season of Is This a Zombie? ended, Ayumu thought his life might finally get back to normal, or as normal as it can be for a zombie. However, destiny has other plans for him. Some guys just can't catch a break. (Source: FUNimation)

Mini episodes of Kotoura-san introducing each of the series' characters.

The year is 2045, and artificial intelligence has undergone tremendous developments. Governments use them as weapons, engaging in never-ending warfare to sustain their economies. The mercenary group GHOST, headed by Major Motoko Kusanagi, is no stranger to this landscape. However, the rapid innovation of this technology causes a new threat to loom over the horizon. Having left Public Security Section 9, Kusanagi and her group are involved in many operations worldwide related to these proxy wars. But a seemingly simple job of locating an arms dealer drags GHOST into a hidden conflict against cybernetically enhanced individuals, who have inexplicably gained extreme intelligence and physical abilities. Dubbed post-humans, their emergence sets off a chain of events leading to the reunion of Section 9. Armed with a new mission, it is up to Kusanagi and her reestablished team to prevent global chaos at the hands of these post-humans.