Fifty years ago, mysterious creatures known as the Huge suddenly appeared all over the world, posing an existential threat to humanity. To defend against these menaces, soldiers in the form of teenage girls known as Lilies use the energy Magie within their bodies to power weapons called Counter Huge ARMS or CHARMS. After being saved by a Lily two years ago while evacuating from a Huge attack, Riri Hitotsuyanagi vowed to become a Lily herself. She enrolls in the prestigious academy of Yurigaoka, a training ground for Lilies, and discovers that one of her classmates is Yuyu Shirai—the same Lily who rescued her. Much to her confusion, however, the person she thought to be cheerful turns out to be quite antisocial and prefers to fight alone. Even so, Riri still desires to get along with Yuyu and is willing to do anything she can to reach that goal. With Yuyu and the other Lilies by her side, Riri's journey on becoming one of them has just bloomed!

Since childhood, Tadahiro Amatsu has two different-colored eyes - one brown and one light hazel. But because of a dark secret behind his left eye, he's become a target for the masked sorcerer Ayatara Miramune and his band of demons. To combat the demons appearing all over town, Yuzu Hieda, a priestess in training, recruits four other girls from her high school. Under the supervision of Yuzu's elder sister Kurako, the five young priestesses must undergo months of training to master their abilities. (Source: ANN)

The discovery of a black crystalline mineral known as Originium has accelerated technological advancement in the world of Terra, with its high energy yield allowing people to demonstrate abilities akin to magic called Arts. Large veins of Originium can naturally be found at the sites of Catastrophes, various forms of natural disasters caused by the mineral itself. However, the usage of Originium comes at a price, as there is a high risk of getting infected with Oripathy—an incurable and highly contagious disease. Because nations subject the infected to harsh discrimination, the oppressed begin a dissident movement. Calling themselves Reunion, the rebel faction mercilessly destroys cities, further contributing to the already calamitous nature of Catastrophes. Rhodes Island, committed to treating the infected and uninfected as equals, is a paramilitary pharmaceutical organization believed to be the most advanced in its research for the Oripathy cure. Unfortunately, the person spearheading the project—an enigmatic figure known only as the Doctor—suffers from amnesia, effectively impeding what might be the only hope for the infected to break free from their chains of despair.

A criminal group known as Demon Seed terrorizes Tokyo with its vast armies of mecha. The local police is afraid to confront them, but one person stands in their way: Maron Namikaze, a 13-year-old idol singer with a catchy voice and unbelievable superhuman strength. (Source: ANN)