Rinka Urushiba works part time as a waitress to help out her unemployed father. By all accounts, her life in Tokyo is a relatively normal one—but her sense of normalcy begins to fade when she inexplicably sees a flying penguin one day. Chasing it all the way to the top of a building, she encounters more surprises, including flying goldfish and another person—a classmate named Kyoutarou Azuma—who can also see these strange things. After Rinka passes out when a goldfish phases through her, she wakes up an esper with the ability to phase her body through solid matter. However, her newfound ability is not the only strange thing about her: when she uses her powers, her hair turns white. Deciding reluctantly to use this new gift to help the city, she becomes Tokyo's new hero, dubbed the White Girl. Along with Kyoutarou, who gained the power of teleportation, Rinka begins righting the wrongs in the city while fighting other espers who have much less noble intentions.

Ichigo Momomiya is excited to start high school and fall in love. She is in luck when she meets the popular and good-looking Masaya Aoyama, and she immediately develops a crush on him. When Ichigo learns that Aoyama is passionate about the environment, she seizes the chance to ask him out thanks to some tickets to an exhibition about endangered animals. During their date, Ichigo is struck by a mysterious light and faints. Waking up to the sight of Aoyama, she remains unharmed—but they both must escape from a giant rat-like creature after it injures Aoyama. To save her crush, Ichigo awakens her powers and transforms into a heroine with the skills of a cat. After she defeats the monster, researchers Ryou Shirogane and Keiichiro Akasaka explain that Ichigo was chosen to become a part of the Mew Project: a group of five magical girls whose DNA has been infused with those of certain endangered species. Now, Ichigo must find the rest of her teammates to defeat the Chimera Anima—beings infected by aliens who want to take over the world—before it is too late.

After the conclusion of the Tsukiyama Family Extermination Operation, the members of the Commission of Counter Ghouls (CCG) have grown exponentially in power and continue to pursue their goal of exterminating every ghoul in Japan. Having resigned from Quinx Squad, the now seemingly emotionless Haise Sasaki begins taking on more and more tasks from the CCG with no regard to the difficulty. Despite his vacant expressions, Ken Kaneki's memories are resurfacing in Haise, leaving him in a state of internal conflict. Meanwhile, his new coldhearted behavior is affecting the people around him. Quinx Squad are left in shambles, having to cope with the death of one of their members without the support of their former mentor. Amidst this turmoil, both Quinx Squad and Haise must continue to fulfill their duties to the CCG, whether willingly or not. However, the presence of a mysterious group behind the CCG has been made known to Haise, and certain whispers of corruption have not gone unheard by the Quinx Squad as well.