Ayato Kamina was separated from the girl he loved, Haruka Mishima, when an event occurred that was thought to have killed everyone outside of Tokyo. But one day three years later, invaders suddenly attacked the city. It was then that he meets an agent of TERRA, Haruka Shitow, who tells him that she will give him the truth about the world. It is the beginning of a series of strange events, which involve him activating a giant mecha, the RahXephon and finding out that many people, including his own mother, has blue blood, and that he was actually living in a self-encased dimension where time moves slower than that of the outside world. (Source: ANN)

In a future where a massive disaster has devastated Earth, most of humanity has abandoned their physical bodies and relocated in digital form to DEVA, an advanced space station orbiting the ravaged planet. Free from the limitations of traditional existence, such as death and hunger, the inhabitants of this virtual reality reside in relative peace until Frontier Setter, a skilled hacker, infiltrates the system and spreads subversive messages to the populace. Labeled a threat to security by authorities, Frontier Setter is pursued by Angela Balzac, a dedicated member of DEVA's law enforcement. When the hacker's signal is traced to Earth, Angela takes on physical form, transferring her consciousness to a clone body and traveling to the world below in order to deal with the menace. On Earth, she is assisted by Dingo, a charismatic agent, and during her journey to uncover the mystery behind Frontier Setter, she gradually discovers startling realities about the wasteland some of humanity still refers to as home, as well as the paradise above.

Said to be humanity's natural enemy, formidable dragons that belong to an ancient bloodline roam the world. Only two ways prove effective to kill a dragon: freezing their blood with silverine—an aura that comes from silver weapons—or letting their bodies be incinerated by sunlight. Young hunter prodigy Leonica is accompanied by her close friend Ragna, who appears to lack the skills necessary in their profession. Moreover, many shun Ragna, considering him cursed because dragons always seem to attack him and slaughter his close ones. Nevertheless, Leonica sees potential in Ragna and gladly partners up with him. Likewise, Ragna feels certain that Leonica is immune to his misfortune thanks to her incredible strength. His confidence is shaken, however, when Ragna dreams of Leonica's death, believing this to be a prophecy. As the destined day arrives, he comes face-to-face with his future self, who bestows him enormous power and memories from the future to ensure Leonica's safety. In order to succeed, Ragna must join forces with a mysterious figure known as Crimson and eradicate all dragons for good.

Specials included in the Blu-ray/DVD volumes. Each special will be about a different character.