10,000 years in the future, the world has become a very different place; monsters roam the land freely, and people, although equipped with high tech weapons and cybernetic horses, live a humble life more suited to centuries past. The story focuses on a small hamlet plagued by monster attacks and living under the shadow of rule by Count Magnus Lee, a powerful vampire lord who has ruled the land for thousands of years. When a young girl is bitten by the Count and chosen as his current plaything, she seeks out help of a quiet wandering stranger, D. It so happens that D is one of the world's best vampire hunters, and he takes it upon himself to cut through Magnus Lee's many minions, and put an end to the Count's rule. (Source: AniDB)

During a winter long ago, near-immortal vampires began plaguing the world. As their population grew at an astounding rate, they promptly threw humanity off its place at the top of the food chain. Desperate to avoid extinction, the surviving humans concentrated in their last safe haven—a small city surrounded by an enormous wall. There, they have waged war against the vampires for many years. In the midst of a particularly brutal attack by the vampires, a human soldier named Momo encounters Fiine, the queen of their enemies. After seeing her try to save Momo's best friend from a rampaging vampire, Momo follows Fiine back to her house. It is there Momo connects with Fiine over their love for music and desire to escape the fighting. Pursuing that goal of escape, the two decide to journey toward a supposed paradise where humans and vampires coexist—despite being uncertain of its existence. However, Momo and Fiine are being targeted by both races, who they must first evade if they hope to reach their destination in one piece.

Evil Shinma (shape-shifting monsters and vampires) roam the Earth on a mission to unleash their darkness upon the Human race. Miyu Royal Princess from the dark is the Chosen One—the one being who must banish the Evil Shinma from the Earth. She has the power to offer Humans the gift of eternal happiness, yet is herself, trapped between two worlds; destined for perpetual solitude and internal conflict. Miyu's only companion is Larva, once an evil Shimna; now her devoted guardian. Together they share a dark journey through the weakness of the human heart and the tragic loss of innocence. Cut off from humanity by the knowledge of what she is, Miyu lives an endless quest as both the hunter and the hunted, on the edge of darkness. (Source: AniDB)

The world is a dark, brooding place populated by humans, but ruled in reality by powerful beings known as the Darkstalkers, and there is constant conflict between them as they try to determine who is the most powerful of them all. Zombies, vampires, werewolves - all of them compete in contests of strength and sheer will to attain their own personal goals. All of this becomes moot when a race of Aztec robots called the Huitzil decide that humanity isn't worth saving, and start waging war on the world, while in the sky, a solar god from outer space plots the conquest of Earth. And the Darkstalkers must become unwilling allies in order to save the world. (Source: AnimeNfo)