The challenger has become the champion as Ippo Makunouchi now wears the featherweight championship belt of Japan. Some time has passed since Ippo's victory, and he has found his friends and coach as supportive as ever; his crush, Kumi Mashiba, seems to enjoy spending time with him as well. Things are looking bright for the new champion, but just as he once set his sights on becoming the best, his first challenger poses an intimidating threat. Kazuki Sanada works as a doctor at the same hospital as Kumi and fights strategically. Known for integrating his knowledge of the human body into his fights, Sanada is a fearsome contender—however, more unnerving than his physical ability, he has garnered the support of the nurses. Despite being the champion, Ippo feels the pressure as he must face the daunting challenge, retain his belt, and win over the girl he loves.

Although the city of Fukuoka might look relatively peaceful at first glance, in actuality it houses a thriving mixture of dangerous individuals such as killers, detectives, and professional revenge seekers right beneath its surface. Among their number is Zenji Banba, a laidback and observant detective who is investigating the work of other hitmen companies in the area. However, Banba might not be the only one with a bone to pick with these organizations, as Xianming Lin, a crossdressing male hitman in the employ of one such company begins getting fed up with his lack of jobs and pay. One day, after Lin's current target commits suicide before the hitman could reach him, his company refuses to pay him even half the amount they were originally supposed to for the assassination. Frustrated, Lin requests another mission and is offered the job of taking out Banba, whom his organization believes has been interfering with their business. However, when Banba arrives at his home and finds the hitman inside, Lin surprisingly doesn't even attempt to kill him. Instead, he offers the detective another option: to join him and form a team. With the offer on the table, exactly how will Banba respond, and just what plans does Lin have in store for the underground world of Fukuoka?

The journey to find all eight sacred gems continues, as Sousuke and Shino travel in search of the remaining gem holders. From the shadows the Imperial Church continues to scheme, and a mysterious woman seeks to fulfill a sinister plot with the gem holders at its heart. As the origin of the gems comes to light, so does the truth behind Sousuke's doppelganger, Ao, as he resurfaces with his own goal—one involving Sousuke and his gem! (Source: Sentai Filmworks)

A courageous young man tries to find the only person who can save his planet from the most terrifying beast in the universe—the great white whale Moby Dick—in this futuristic anime adventure set in 4699. But locating the outlaw Captain Ahab and his illusory crew of whale hunters and persuading them to put an end to the leviathan's long reign of terror won't be easy. Will Ahab take up the challenge one more time?