In ancient times, a great battle was waged between a master mage, Enno Ozuno, and an evil demon goddess, Karuma. Unfortunately, Enno didn't have the strength to defeat her alone and was forced to call upon Zenki, a powerful protector demon. After Karuma was defeated, Enno sealed Zenki away in a pillar located inside his temple. 1,200 years after this epic battle, Enno's descendant, Chiaki, spends her days showing tourists around her hometown of Shikigami-cho and doing exorcisms to pay the bills. One day, two thieves enter the town in hopes of opening a seal in the Ozuno temple and releasing the hidden treasure from within. However, what actually pops out is a dark entity that attaches itself to the henchmen, transforming them into demonic beings. After this transformation, they begin a rampage through the temple, terrorizing poor Chiaki. It is now up to this young progeny to unleash her family's powers to summon Zenki and save Shikigami-cho from these demons, as well as the evil entities sure to follow in their footsteps.

All of a sudden, they arrived: parasitic aliens that descended upon Earth and quickly infiltrated humanity by burrowing into the brains of vulnerable targets. These insatiable beings acquire full control of their host and are able to morph into a variety of forms in order to feed on unsuspecting prey. Sixteen-year-old high school student Shinichi Izumi falls victim to one of these parasites, but it fails to take over his brain, ending up in his right hand instead. Unable to relocate, the parasite, now named Migi, has no choice but to rely on Shinichi in order to stay alive. Thus, the pair is forced into an uneasy coexistence and must defend themselves from hostile parasites that hope to eradicate this new threat to their species.

Alto Goldfilled, a diligent student at the Ortigia Academy of Magic, aspires to become a powerful sorcerer. But he is unable to become one as, despite his excellent grades and strong commitment to his studies, he fails his summoning class. With the threat of repeating a year hanging over his head, Alto tries following an old, worn-out grimoire in a desperate attempt to resolve his situation. To his surprise, he succeeds and summons a powerful demon named Vermeil. As a sign of gratitude for releasing her, Vermeil agrees to become Alto's familiar, sealing their relationship with a deep kiss. Little does Alto know what else he is capable of and what Vermeil's past hides.

Kishibe Rohan wa Ugokanai adapts a handful of one-shots based on the manga series JoJo no Kimyou na Bouken, and follows the bizarre adventures that Rohan Kishibe goes through as he searches for inspiration for his manga. Fugou Mura Rohan accompanies manga editor Kyouka Izumi to a secretive village where she plans on buying a house. Izumi informs Rohan that inhabitants of the village suddenly become rich at the age of 25 after purchasing their homes. Being 25 years old herself, Izumi has high hopes for moving into the village and invites Rohan to gather ideas for his manga. As they enter one of the houses for an interview with the seller, they are greeted by a servant named Ikkyuu, who puts them through a test of etiquette with deadly consequences. Mutsukabezaka Rohan meets with his editor, Minoru Kagamari, to discuss both his manga and the six mountains that the manga author recently bought. He explains that he purchased the mountains in order to search for a legendary spirit known as the Mutsukabezaka. To give his search context, he tells the tale of Naoko Osato, a wealthy heiress who murdered her boyfriend and became cursed by the spirit. Zangenshitsu Rohan decides to vacation in Venice after putting his manga on hiatus. While there, he explores the interior of a church and examines the structure of its confessional. After stepping into the priest's compartment, Rohan hears a man enter the confessional and begin to confess his sins. The man recounts his confrontation with a starving beggar and the haunting events that followed. The Run Youma Hashimoto is a young male model who has quickly risen to success. As his popularity grows, so does his obsession with his appearance and body. One day, he meets Rohan at the gym, and the two quickly form a rivalry which pushes Youma to intensify his training. Soon. Youma's fixation on his physique takes a dark turn as his training takes precedence over his life, and he challenges Rohan to a fatal competition on the treadmills.