With the conclusion of her favorite romance manga, Fuuko Izumo is ready to end her life of misery and loneliness having long accepted her fate of never being able to experience passionate love like fictional characters. Cursed with unluck, anyone Fuuko touches is in grave danger of experiencing unimaginable calamity. While the possibility of imminent danger would have most sane people run in the opposite direction, Undead has other ideas. He is an immortal being with superhuman regenerative powers desperately seeking death, which has always eluded him. When their paths finally cross, Undead sees an opportunity to finally end his suffering by using Fuuko's unluck. But before Undead can unlock the full potential of Fuuko's power to trigger the final devastating blow, the duo must first fend off a murderous secret organization hell-bent on exterminating those with special abilities.

After succeeding in their winter conflict against Taiju Shiba and his Black Dragons, the Tokyo Manji Gang absorbs their group's remaining members. Due to his heroic courage and indomitable spirit, Takemichi Hanagaki should have accomplished his goal of defeating the tragic fate awaiting his girlfriend, Hinata Tachibana. In reality, Takemichi's troubles are far from over. Although Takemichi's actions have exposed Tetta Kisaki's treachery, the conniving schemer has found power elsewhere: Tenjiku, a dangerous gang led by the enigmatic Izana Kurokawa. Izana sets his sights on Manjirou Mikey Sano, pursuing a vicious interest in the Tokyo Manji Gang's aloof leader. In the future, Takemichi discovers that the machinations of Izana and Kisaki led to Mikey's moral ruin—a downfall that directly results in Hinata's death. Unfortunately, a terrible loss robs Takemichi of his time-leaping ability, stranding him in the past with one final chance to rescue everyone he loves.

Despite returning victorious from a dangerous struggle, Kanata and his friends have, in a sense, lost a key ally, the amnesiac magus Noir. Having partially recovered her memory, Noir reverted back to her former personality: that of Mystere, who acts in a patronizing manner toward her master Kanata. However, Mystere remembers detecting a signal from Histoire, a mystical city, during her former life as an artificially intelligent magus. Meanwhile, Tokio disappears from Rock Town while hunting down the ghosts of his past; however, shocking revelations await the deeper his search goes. As Kanata, his childhood friend Ellie, and the magus diva Ciel set out for Histoire, a hostile organization named Ideal sends assassins after them. If Kanata wants to stand a chance at accomplishing his dream, he must uncover the unpleasant truth about Ideal—and some of his closest allies.

Second season of High Card.