Lupin, Goemon, and Jigen take a mini-helicopter and head to the mysterious “Drifting Island” looking for a treasure rumored to be hidden somewhere on it. Through their exploration of the island, the trio encounters the lethal “Nanomachine,” the island’s security system. The trio triggers the alarm, springing “the Nanomachine” to life. The key to solving the island’s mystery lies in the small nation of Zufu. This once prosperous nation is now ruled by the ruthless, knife-collecting, General Headhunter. Fujiko does her usual probing and hacks into General Headhunter’s computer hoping to find some crucial information. Zenigata has received a video message from Lupin in which Lupin announces his desire for the priceless treasure. Oleander, a fiery blond officer with some hidden secrets of her own, steps in to help Zenigata. Armed with their newly found information, Lupin, Goemon, Jigen, and Fujiko go back to “Drifting Island,” but this time they are followed by General Headhunter. (Source: ANN)

Mysterious Babylonian Tablets unearthed in Manhattan provide tantilizing clues about the location of the Tower of Babel - not the biblical one, but the original one, built out of solid gold! The Mob is out to get the gold, but so is Lupin III. It's Thugs vs. Thieves when Lupin & Co. go up against a fearsome flyswatting Polish Mafia boss, a bevy of beauty-contest policewomen, Zenigata, the hard-luck Interpol Inspector, a mysterious bag-lady AND his own girl-friend in a trans-continental trust-nobody trek after a treasure of biblical proportions! (Source: AniDB)

Zenigata arrives on the ship Machine Gun Kelly, a casino on the water owned by the mafia, because Lupin plans on stealing the casino's money. Lupin and his gang manages to break into the ship's vault but was unable to escape with the money due to Zenigata's shooting. However, there was another purpose the ship had, one that Lupin was aware of; to search for a sunken ship filled with gold. Lupin managed to steal this data while he was on the ship, however, now they have to contend with Zenigata, the mafia, and a secret organization whose base is under Alcatraz, as they attempt to uncover the secret behind the organization and the sunken treasure. (Source: ANN)

When Fujiko acquires and memorizes papers called the Columbus Files, she is attacked and loses her memory. Lupin, a treasure hunter named Rosaria, and the cackling villain Nazaroff all pursue Fujiko, as she is the only key to the location of Columbus' Egg, a treasure connected to the mysterious Orgone Energy. (Source: ANN)