A runaway vehicle driven by Izumi Yasaka, en route to the Public Safety Bureau building, is reported shortly before it crashes into the building. Izumi is a counselor who recently ran away while working at a latent criminal isolation and rehabilitation facility known as Sanctuary. Before Inspectors Mika Shimotsuki and Akane Tsunemori get to interrogate the suspect, a sudden request is issued from the facility to promptly bring Izumi back. Interpreted as a direct order from the Chief and the board at Sanctuary, the Inspectors obey, but insist that Izumi be escorted back personally. Tsunemori intends to investigate further with the rest of the team at the Bureau. Now Inspector Shimotsuki has finally been given the opportunity she had been waiting for—to be the primary investigator on an important case. This case follows Shimotsuki and her team of Enforcers as they uncover the secrets of Sanctuary.

Thirty years ago, a new race of flame-wielding mutants suddenly appeared, destroying a large portion of humanity. These so-called “Burnish” have continued to appear at random, leaving a trail of death and destruction in their wake. The autonomous republic of Promepolis is a thriving nation thanks to the incredible efforts of their leader, Kray Foresight, against the Burnish. A team of firefighters known as the Burning Rescue is tasked with stopping these horrifying monsters, using the most performant technology available thanks to their incredible mechanic Lucia Fex. Galo Thymos is an energetic young man, who considers Foresight his hero for saving his life and is the rescue team's most recent recruit. A terrorist group calling themselves Mad Burnish has been causing havoc all over the nation. After an encounter with Mad Burnish leader Lio Fotia, Galo sets out on his fated journey to find the truth about these mutants, ultimately leading him to question everything he previously held to be true.

The Garadain Empire has exhausted the primary resources of their native planet, so they send different space expeditions to find a new world where to live. One of their main objectives is planet Earth. However, Zeku Alba, an alien scientist, decides to rebel against the imperial rule and flees towards the Earth, where he gathers a group of youngs gifted with the power of psychogenesis, an ability that consists in creating solid matter from mental energy. The most gifted of the squadron is Isamu, a young orphan whose family was killed in the first attack of the Garadain Empire. He is able to generate the powerful robot Govarian, an armor with which he can battle the alien monsters and is able to regenerate thanks to the psychic energy of the pilot. Helped by two other robots created by his team-mates, Isamu, aboard the robot Govarian, defends the Earth in the long war against the alien invaders. (Source: Wikipedia)

Shinya Kougami continues to wander the Southeast Asian Union (SEAUn) away from the eyes of the Sibyl System in Japan. While traveling through the Tibet-Himalayan Alliance Kingdom, Kougami encounters Guillermo Garcia—commander of a paramilitary group attempting to unite the local factions and bring peace to the war-torn nation. Wary of joining another mercenary group, Kougami declines to join his cause, but agrees to be driven to the nearby Tibetan capital by one of Garcia's men. However, Kougami's plan to remain uninvolved is short-lived when a bus of refugees are ambushed by armed guerrillas. Among them is a half-Japanese, half-Tibetan girl named Tenzing Wangchuck. Impressed with Kougami's fighting prowess as he single-handedly takes the attackers out, Wangchuck requests him to teach her how to fight so she can take revenge against the warlord who murdered her family. Knowing first-hand that there is no turning back to the person you were once you take a human life, Kougami is initially reluctant to accept her request. But faced with the girl's desire for vengeance that mirrors the haunting abyss inside his own heart, will he train her?