Holo is a powerful wolf deity who is revered in the small town of Pasloe for blessing the annual harvest. Yet as years go by and the villagers become more self-sufficient, Holo has been reduced to a mere folktale. When a traveling merchant named Kraft Lawrence stops at the settlement, Holo offers to become his business partner if he takes her to her northern home of Yoitsu. The savvy trader recognizes Holo's unusual ability to evaluate a person's character and accepts her proposition. Now in the possession of both sharp bargaining skills and a charismatic negotiator, Lawrence inches closer to his goal of opening his own shop. However, as Lawrence travels the countryside with Holo in search of economic opportunities, he begins to realize that his aspirations are slowly morphing into something unexpected.

The comedy revolves around Sayuri Satou, the new front desk worker at the Sparrow's Hotel—the closest hotel to Heaven. Her special features are her large breasts and her skills of assassination. She takes down people who cause trouble in the business hotel with those skills, but she is in fact very unskilled when talking to the male hotel manager, and often bites her tongue. (Source: ANN)

Ten years after the Bubble War, the dichotomy between the rich and the poor in the world becomes more prominent and Japan is no exception. The rich seek to satisfy their desires and derive pleasure for themselves, and Tokyo has materialized into such a city as a result. Saiga, once a war photographer, works for Hibara Ginza in the capitalist state of Tokyo. He infiltrates the Roppongi Club, a secretive base located in the red light district of the city, to collect information about them. However, he was caught in the process and brought forward to a girl called Kagura who was in the midst of a ritual. His contact with Kagura awakens his special ability: the power to make things explode when photographed. In order to unravel the mystery behind the Roppongi Club and Kagura, Saiga begins his solitary battle.

Drugs have become the center of conflict in Japan, and crime involving them has been increasing at an alarming rate. Unable to control the chaos, the police department settled on creating a unit—STAND—that would include unique, specialized experts and professionals better suited to handle the pressing issue. Rei Izumi is a novice joining the narcotics investigation unit, assigned the daunting task of recruiting the potential representatives of STAND. While recommended for her moral sense of justice and devotion to police work, Rei also has a unique aspect of her own that may have earned her the job—she has an immunity to many, if not most, kinds of drugs. Eager to seek the possible members of STAND, Rei quickly learns that scouting the different individuals will be more difficult than she expected, as each candidate harbors their own feelings, ideologies, and willingness toward joining the team and regulating drugs as a whole. Her capability as a narcotics officer is also questioned by the many colorful personalities she meets, stirring conflict and unpredictability in Rei's daily life. However, persuading the various contenders for STAND isn't the only obstacle she faces, as becoming involved in the treacherous underworld of drugs, overflowing with deceit and secrecy, will be more hazardous than she ever imagined.