In the world of Duel Monsters, a new generation of duelists await their turn to bid for the highest title: The King of Games. As an aspiring duelist, the happy-go-lucky Juudai Yuuki enrolls at the Duel Academy, a reputable institution tasked with nurturing these potential challengers. On his first day, however, Juudai's laid back and careless attitude causes him to arrive late to his entrance exam. There, he stumbles upon a familiar figure who entrusts him the Winged Kuriboh, a card which becomes Judai's new partner. Soon, he begins living as a duelist—but will destiny and darkness bend his reality into something beyond his imagination? Yu☆Gi☆Oh!: Duel Monsters GX follows the story of Juudai as he strives to fulfill his goal of becoming the next King of Games. As they are thrust into countless unprecedented circumstances, one thing is for sure for Juudai and his friends—there will never be a dull moment at the Duel Academy!

Bullies often target someone frail and weak—someone exactly like Yuugi Mutou. His beautiful childhood friend, Anzu Mazaki, is always there to stand up for him, but he can't depend on her forever. Katsuya Jonouchi, who is almost always accompanied by his verbal sparring partner Hiroto Honda, doesn't seem like a bad person either, despite always bringing Yuugi trouble. But most of all, Yuugi wishes for a true friend who understands him and would never betray him. Yuugi treasures his Millennium Puzzle, an ancient Egyptian artifact that was brought into his grandfather's game shop. Believing that solving the puzzle will grant him his wish, he completes the puzzle, unleashing a new personality within him—the soul of the King of Games. Dark, twisted, strong, and reliable, the new personality named Yami Yuugi is the exact opposite of Yuugi. Upon any injustice toward him, Yami Yuugi takes over Yuugi's body and forces the opponent into a Shadow Game. The stakes are high as whoever loses shall have a taste of the darkness that resides within their own heart.

Anubis, an ancient Egyptian evil that was defeated by Yugi's alter ego centuries ago, has returned to exact revenge. Wielding the power of the Eighth Millennium Item, Anubis is determined to destroy Yugi and take over the world. (Source: ANN)

The card game Duel Monsters has become all the rage in Domino City. The rules are simple: two players, known as Duelists, fight each other with the monster cards they have collected in their decks and deduct Life Points. Each Duelist starts with a total of two thousand Life Points, and whoever loses all of them first is defeated in the battle. One day, a timid boy named Shougo Aoyama buys a deck that contains the Red Eyes Black Dragon, a legendary card said to bring victory to those courageous enough to fight. Soon, word of the card in Shougo's hands begins to spread, eventually reaching the competitive Duelist Seto Kaiba. Desiring to collect the strongest cards in any way possible, Kaiba invites Shougo and his rival Yuugi Mutou to a Duel Monsters tournament—but will Shougo be able to overcome his fear of losing?