In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him.

It has been 10 years since the war between the Iga and Kouga ninja clans came to an end. The two groups have since made peace, supposedly dispelling the animosity that once existed between them. Hachirou Kouga and Hibiki Iga, the successors of their respective bloodlines, seem to have the perfect conditions for their love to bloom, but not everyone is satisfied with the results of the age-old battle. Different tales of the final showdown between Gennosuke Kouga and Oboro Iga have spread, leaving Tadanaga Tokugawa—whom the Kouga represented—dissatisfied. As tension between the two clans rises once again, the brewing political climate threatens to keep the two fated lovers apart, just as it had in the previous generation.

Hidden in the backstreets of the Ginza district is Eden Hall, a lone bar operated by Ryuu Sasakura, the prodigy bartender who is said to mix the most incredible cocktails anyone has ever tasted. However, not just anyone can find Eden Hall; rather, it is Eden Hall that must find those who need it. Customers of varying backgrounds, each plagued with their own troubles, wander into this bar. Nevertheless, Ryuu always knows the ideal cocktail to console and guide each distraught soul.

Fleeing a traumatic childhood, lone mercenary Guts drifts from battle to battle, striking down powerful enemies with his unwieldy sword. After one skirmish, Guts clashes with the mystifying Griffith and his small army known as the Band of the Hawk. The victorious Griffith drafts Guts into his ranks, granting the swordsman a kinship unlike anything he has ever known. Alongside the skilled warrior Casca, Guts helps Griffith guide the band to fame and glory. But as he gains military prestige, Griffith becomes the target of assassination attempts and political schemes. He uses Guts to further his ambitious rise to power, taking advantage of the swordsman's lack of aspiration. Even as he grows closer to Casca, Guts' absence of direction robs him of any sense of belonging. Fostering opposing desires, Guts and Casca fight for Griffith's dream—although fractures forming among the trio threaten to disrupt their world.