A strange environmental phenomenon 22 years ago in the Kanazawa prefecture caused the land to split and protrude upwards reaching unprecedented heights, creating the secluded area known as The Lost Ground. Kazuma is a young mercenary who lives in the Lost Ground, looking for any work he can find to sustain his livelihood within the harsh environment. He is one of the few people that are gifted with the Alter ability, which allows him to plaster his right arm and torso with a metallic alloy. When this mercenary encounters HOLY, an order whose purpose is to suppress and capture what they call Native Alter Users, and one of the elite members of HOLY, Ryuho, an epic rivalry begins. (Source: ANN)

Born to the royal family, Pacifica Casull has earned the nickname Scrapped Princess after an apocalyptic prophecy foretells her destroying the world on her 16th birthday. Rescued from certain death by a kindly family, she takes shelter with her adoptive older brother and sister, Shannon and Raquel Casull. When news of her survival reaches the ears of the God Mauser's worshippers, they issue her death at all costs, forcing Pacifica to flee for her life. Plagued by threats from the church, the nobility and even the common people, the three siblings attempt to outrun the fate Pacifica is destined to bring, all the while questioning if one girl's life is worth the world's demise. The true nature of the Scrapped Princess, along with the harrowing revelations of the world itself, becomes more and more apparent as the princess' 16th birthday fast approaches.

Harry is definitely not your average American teenager. Instead, he is the epitome of an alienated youth—friendless at school, extremely weird, and nervous to the point of paranoia. But a chance occurrence causes Harry to start to demonstrate what appear to be psychic powers—yet he neither believes in them nor consciously controls them. However, there are other ominous forces at work who do believe in Harry and attempt to make use of him in ways that are threatening and frightful. (Source: AniDB, edited)

The rare and inexplicable Puberty Syndrome is thought of as a myth. It is a rare disease which only affects teenagers, and its symptoms are so supernatural that hardly anyone recognizes it as a legitimate occurrence. However, high school student Sakuta Azusagawa knows from personal experience that it is very much real, and happens to be quite prevalent in his school. Mai Sakurajima is a third-year high school student who gained fame in her youth as a child actress, but recently halted her promising career for reasons unknown to the public. With an air of unapproachability, she is well known throughout the school, but none dare interact with her—that is until Sakuta sees her wandering the library in a bunny girl costume. Despite the getup, no one seems to notice her, and after confronting her, he realizes that she is another victim of Puberty Syndrome. As Sakuta tries to help Mai through her predicament, his actions bring him into contact with more girls afflicted with the elusive disease.