Night Raid is the covert assassination branch of the Revolutionary Army, an uprising assembled to overthrow Prime Minister Honest, whose avarice and greed for power has led him to take advantage of the child emperor's inexperience. Without a strong and benevolent leader, the rest of the nation is left to drown in poverty, strife, and ruin. Though the Night Raid members are all experienced killers, they understand that taking lives is far from commendable and that they will likely face retribution as they mercilessly eliminate anyone who stands in the revolution's way. This merry band of assassins' newest member is Tatsumi, a naïve boy from a remote village who had embarked on a journey to help his impoverished hometown and was won over by not only Night Raid's ideals, but also their resolve. Akame ga Kill! follows Tatsumi as he fights the Empire and comes face-to-face with powerful weapons, enemy assassins, challenges to his own morals and values, and ultimately, what it truly means to be an assassin with a cause.

After escaping certain death, Kei Nagai and his new companion Kou Nakano plot revenge on Satou, their fellow Ajin who is hellbent on world domination. As Satou embarks on a string of public executions, the human race rushes to come up with a solution to stop the immortal villain. Kei discovers unlikely allies in the form of two former adversaries: high-ranking government official Yuu Tosaki, whose extensive research on Ajin gives him a tactical advantage in the fight against Satou, and Tosaki's Ajin assistant Izumi Shimomura. As his faction continues to gather allies, Kei races against time to put a stop to Satou's crusade before it brings about an end to civilization as he knows it.

The bustling metropolis of Kansai, where cybernetic screens litter the neon landscape, may seem like a technological utopia at first glance. But in the dark alleys around the brightly-lit buildings, an unforgiving criminal underbelly still exists in the form of fugitives known as Akudama. No stranger to these individuals, Kansai police begin the countdown to the public execution of an infamous Akudama Cutthroat, guilty of killing 999 people. However, a mysterious message is sent to several elite Akudama, enlisting them to free Cutthroat for a substantial amount of money. An invisible hand seeks to gather these dangerous personas in one place, ensuring that the execution is well underway to becoming a full-blown bloodbath.

Japan, 1988. An explosion caused by a young boy with psychic powers tears through the city of Tokyo and ignites the fuse that leads to World War III. In order to prevent any further destruction, he is captured and taken into custody, never to be heard from again. Now, in the year 2019, a restored version of the city known as Neo-Tokyo—an area rife with gang violence and terrorism against the current government—stands in its place. Here, Shoutarou Kaneda leads the Capsules, a group of misfits known for riding large, custom motorcycles and being in constant conflict with their rivals the Clowns. During one of these battles, Shoutarou's best friend Tetsuo Shima is caught up in an accident with an esper who finds himself in the streets of Tokyo after escaping confinement from a government institution. Through this encounter, Tetsuo begins to develop his own mysterious abilities, as the government seeks to quarantine this latest psychic in a desperate attempt to prevent him from unleashing the destructive power that could once again bring the city to its knees.