Tensions from the Selector battles have seemingly vanished, and the remaining participants have quickly put the entire ordeal behind them. However, Kiyoi Mizushima feels that the conflict has yet to end. Despite Kou Satomi's defeat, his supporters are already attempting to revive his plans in the background. It does not take long for Mizushima's suspicions to be confirmed true. Not only does the Selector battle system reemerge, but also a new mechanic has been implemented. Players receive a special key card that will unlock with gold coins, releasing a hidden power. Aware of the formidable foes that lie ahead, Mizushima begins to seek out skilled allies in her endeavor to finally break the cycle of darkness.

Having moved away due to family circumstances, Suzuko Homura returns to her hometown, nostalgic about the cheerful childhood she shared with Chinatsu Morikawa. Forever sealed with a promise of friendship, those days remain a bright memory to Suzuko, yet she has lost contact with Chinatsu during their time apart. Ready to start anew, Suzuko endeavors to put the past behind her and make new friends at school, but she struggles to do so. Meanwhile, Chinatsu is working multiple shifts to support her family as she continues her studies, and the mounting pressure to meet high expectations soon becomes overwhelming. Amid their respective situations, both girls begin playing the popular card game WIXOSS and discover that they have been chosen as Selectors—players whose memories are now represented by gold coins and must battle other Selectors to earn five of them. Guided by their LRIG avatar cards, which are created from the user's memories, the two learn that inconsistently partaking in duels or losing all their coins will result in a grim outcome. Resolved to protect what they hold dear, Suzuko and Chinatsu prepare for the battles ahead and fight for the chance to reclaim themselves.

For many girls in N-City, playing the popular social role-playing game Magical Girl Raising Project is as close as they could come to being a real magical girl. However, for some rare players, that dream can become a reality. One such girl is Koyuki Himekawa, who receives a notification one night that she has been selected to become a magical girl, her in-game avatar Snow White. As Koyuki and other chosen players in the city begin helping those in need, they all receive yet another notification: the admins have decided that they want to reduce the number of magical girls. Whoever collects the least amount of Magical Candies—which are awarded for their magical girl activities—in their competition each week will lose their powers. But when a real-world tragedy happens to the first player that drops out, they are shown the repercussions of losing their abilities. As more participants inevitably lose the competition and more twisted rules are added, the girls soon realize that their contest is actually a desperate fight for survival.

After narrowly escaping a deathtrap, a dazed Ning Yuan finds himself confined by a menacing gangster, He Zhiyang, alongside hysterical doctor, Su Jin. However, this proves to be the least of his concerns as he comes to terms with the group's newfound desperate situation: they are trapped on an isolated island that harbors malignant viruses, horrid mutations, and hostile tribes. Meanwhile, another group of individuals in the same vicinity happen to face the same predicament. Forced to put aside their differences and come together to fight their way to freedom, the two groups of stranded victims must resist their personal motivations which threaten to get the better of them.