United States Special Agent Leon S. Kennedy sneaks into a small Eastern European country to verify rumors that Bio Organic Weapons (B.O.W.s) are being used in war. Right after his infiltration, the U.S. government orders him to leave immediately. Determined to uncover the truth, Leon ignores the order and enters the battlefield to end the chain of tragedies caused by the B.O.W.s. (Source: IMDB)

The story is set in autumn 2005, one year after Resident Evil 4 game took place. Due to an as of yet unexplained reason, zombies appear in a United States airport. The release of the zombies leads to danger of an outbreak.

Immortality is something many people would wish for. But would it be such a coveted ability if people knew they would be subject to countless attacks because of it? Such is the case for Rin Asougi, an immortal private investigator, because there is no shortage of people who want her dead. Over the centuries, she has met many grisly ends, but each time, she returns to life as if nothing had happened. In 1990, while looking for a lost cat, Rin runs into Kouki Maeno, a man who feels that his memories are wrong. Agreeing to help him, Rin discovers that Kouki is not what he seems, all the while drawing closer to her true enemy. This adversary knows Rin and her kind all too well, and if she dies by his hand, she may stay dead permanently.

Kousuke Mikado has been able to see spirits for as long as he can remember. Extremely terrified of them, he tries to suppress his ability by wearing glasses. One day, while working at a bookstore, he catches the attention of Rihito Hiyakawa, an eccentric medium who is convinced that they were destined to meet each other. Thanks to Hiyakawa's antics, Mikado is thrust into the world of the paranormal, with the former promising that he will shed his fears if Mikado stays with him. As they continue to work together, the two discover a series of malicious curses that all point to the same name—Erika Hiura. What is this person's goal, and how do they connect with Mikado and Hiyakawa?