Harukaze Doremi considers herself to be the unluckiest girl in the world. Her parents are always fighting, her little sister makes fun of her, and her crush pines after another girl. If only Doremi could just wave a magic wand, she would have a much better life—or so she used to think. After a mishap with a real witch, Doremi becomes an apprentice witch herself, and it turns out she's pretty horrible at that, too. Now she and her two friends must study to become better at magic so they can become good witches. That is, if they can focus on their magic studies! The three apprentices will need all the luck they can get if they want to pass the witch exams and become full-fledged witches. Only then will Doremi's debt to the witch Majorika be repaid. Until then, Doremi will remain a useless little witch girl!

The Evil Forces of Dark Joker are closing in on our planet after having destroyed the beautiful planet of Queen Earth. Now, 10 year old Moriya Ririka, with the help of her childhood friend Seiya and the mysterious Kanon, must transform into the Nurse Angel and find the elusive Flower of Life, the only way to defeat the evil forces. The Flower of Life, that once bloomed all over the Earth, is where no one thought it ever would be. And Ririka must make the hardest decision of her life in order to acquire it and rid the universe of evil once and for all. (Source: ANN)

Ungrar, the King of Viruses, has escaped from his prison cell in Vaccine World. Maya, the Goddess of Vaccine World sends Mugimaru down to Earth to find a human to accept the powers of Vaccine World and become the Magical Nurse. He finds the best (and the only willing) person for the job when he meets Komugi Nakahara. Komugi is a playful, lazy, and easily distracted (typical) teenager whose dream is to become a cosplay idol. Balancing her career with the Kiri-Pro Promotion Company and her new job battling Ungrar's loyal henchman, the Magical Maid Koyori, Komugi delights audiences in this parody anime series. (Source: ANN)

At the end of the first season, Doremi and her friends all had to give up their witch powers and be normal girls again. This also meant that they couldn't see Majorika, Lala, and the fairies again. The MAHO-Dou was also deserted and the door to the Majokai was locked. The Queen, having seen all this through her crystal ball, secretly makes it so that Doremi and co. all end up heading into the Majokai again, with the excuse to return Majorika's hair dryer. However they end up stumbling into a garden, and one of the roses reveals a baby! The Queen tells the girls that they must raise the baby for a whole year. To help them, they receive newer and stronger witch powers than before! The adventure isn't over yet!