Since the death of his parents, Shinpei Ajiro had lived with the Kofune family and their two daughters—Mio and Ushio. Although he then left his home island to continue his education in Tokyo, Shinpei returns after Ushio tragically drowns during the attempted rescue of a little girl. During the funeral, his best friend informs him about bruises found around Ushio's neck, casting doubt over the cause of her death. Suspecting a murder has taken place, Shinpei reevaluates recent events, but strange incidents only continue to transpire. Disappearing people and other unexplainable occurrences lead Mio to recall an old folktale referring to entities called Shadows, which may not be entirely fantasy. Supposedly, an encounter with one's Shadow foretells the person's impending demise. Facing the dark side of Hitogashima Island, Shinpei stands against his grim fate to fulfill Ushio's final will—to protect Mio.

At Hope's Peak Academy, a school full of extraordinarily talented individuals, Nagito Komaeda is an ordinary boy with no special traits or interesting skills to speak of—except for his incredible unluckiness. Just walking to school in the morning leads to a number of unfortunate accidents, which only escalate as the day goes on. Despite this, Komaeda leads a relatively normal life and is satisfied with his modest slice of happiness. But everything changes when a mysterious boy who declares himself the Destroyer of the World arrives to shatter this hopeless paradise.

Honda, Kawasaki, and Suzuki all comprise the elite ninth unit of the Sushi Police—a task force with the sole objective of sniffing out restaurants serving illicit or non-traditional sushi and eradicating them, no matter how insignificant their offense may be. The Sushi Police travel freely around the world in pursuit of these vile criminals day or night, with their strong sense of justice and the World Food-Culture Conservation Organization backing them. No offenders of Japan's traditional cuisine can escape their wrath! During one of their purification missions, the Sushi Police encounter Sara—a hot, young, television reporter out to expose them and the World Food-Culture Conservation Organization for corruption. They interrogate her, but her wiles, skills, and charms allow her to easily escape from their grasp, setting off a chain of events that will lead to the true purpose of the Sushi Police being revealed.

Two new members of Japan's Narcotics Control Department are tasked with dismantling the criminal network that supplies the deadly drug called Funny Angel (FA). While Haru Kurabayashi infiltrates the mafia branch that commercializes this drug, his partner Kai Etou starts working in a suspicious greenhouse that may harbor the FA production. As both agents grow closer to their objective, they are confronted with difficult choices that threaten to jeopardize the cover of each other.