For most people, wearing glasses is a necessity for clear sight, but for four young girls, their spectacles mean so much more. From a teenage girl wearing her glasses with pride and a top idol who uses hers to disguise herself as a regular person, to a couple whose bent frames bring them closer together, a good pair of glasses can not only open your eyes, but also open your heart.

In the great city of Metropolis, severe community structures and prejudice dominate a world where humans and robots live together. Unrest and violence increase with each new day. Searching for the scientist Dr. Laughton, suspected to violate human rights by trading organs, the Japanese detective Shunsaku Ban and his nephew Kenichi arrive at Metropolis. In the scientist's laboratory, Kenichi discovers a girl without any memory of her past life. He decides to help her, so they run away together. His uncle follows him and penetrates the dark secrets of the city to find Duke Red, the man ruling from the shadows. Meanwhile, Kenichi desperately tries to protect the mysterious girl from the people hunting her. However, Duke Red and his adoptive son have their own deep reasons for chasing the girl. These reasons are connected to her true identity and the struggle for the domination of Metropolis...

Twelve-year-old Koushi Nagumo's life suddenly goes downhill when his father abandons him after their house burns down. Left to fend for himself, Koushi collapses on the street, but an eccentric woman named Mineru Wachi takes pity on him and brings him to the female dormitory Megami-ryou. After learning of Koushi's situation, Mineru, who happens to be the temporary manager, invites him to become Megami-ryou's official dormitory mother. However, what awaits him are the dorm's residents—each with their own wacky shenanigans—like the androphobic yet gentle Atena Saotome, the feminine tomboy Kiriya Senshou, and Mineru herself, whose recklessness knows no bounds when it comes to science. Despite this, Koushi does his best to fulfill the duties of this crazy new life!

There isn't a single person in Sakuradamon High who hasn't heard the legends about Seiji The Mad Dog Sawamura's demonically powerful right hand. His reputation makes it fairly difficult for him to approach girls, and after being rejected 20 times straight, he half-jokingly vows to finish high school with his right hand for a girlfriend. Much to his surprise, after waking up the next morning, Seiji discovers that his demon right hand has mysteriously turned into a miniature girl, Midori Kasugano, who reveals that she has had a crush on Seiji for the past three years. Because their situation is not ideal for either of them, Seiji attempts to return Midori to normal. But after causing a big misunderstanding at the Kasugano household, the pair decide to keep their predicament between them until a solution is found. Thus begins an odd relationship, and what could be the only chance for Midori to finally be with the one she loves.