High schooler Aoi Mashiro moved from home six months ago, but her recent breakup has made her want to return to tell off her ex-boyfriend. In need of money for a train ticket, she steals two hanging scrolls from her grandfather's attic and takes them to be appraised at an antique shop in the heart of Kyoto's Teramachi Sanjou shopping district. Little does she know that a fateful encounter awaits her during this visit. Upon entering the shop, Aoi is greeted by Kiyotaka Yagashira, the owner's grandson and a graduate student at Kyoto University. Nicknamed Holmes for a pun involving his surname, as well as for his incredible deductive skills, Kiyotaka inspects the scrolls that Aoi brought with her. Based on the items she selected to sell, Kiyotaka senses that Aoi possesses great intuition not unlike his own. Seeing her potential and sympathizing with her story, Kiyotaka offers Aoi a part-time job so she can earn the required money herself. Aoi and Kiyotaka begin working together soon after—not only within the antique shop, but also around town whenever the locals ask for help with their various problems. With Kiyotaka's deduction and Aoi's intuition, no case is too tough for this modern-day Holmes and Watson duo!

Habahiro Hige is a simple-minded older man who works an office job and is an enthusiast of Tabekko Marshmallows. His days often consist of being teased by his 24-year-old colleague Iori Wakabayashi, who uses his obsession to her advantage: from eating them in front of his face, to buying out his favorite brand from the convenience store, and even embarrassing him in front of their boss. Although her friends cannot fathom what she sees in him, she just cannot get over his marshmallow-like, fluffy frame. No matter the lengths it takes, Iori will find a way to get his attention. Little does Habahiro know that she is trying to seduce him into a romantic relationship with her. The way to a man's heart is through his stomach, right? At least this is what Iori would honestly like to believe. With a bag in hand, Iori continues to make him chase after her day after day, hoping that he will finally see through her attempts. Will he ever realize that their relationship can become s'more?

The maid Lilith, hired to look after young Yuuri and his family's mansion, seems highly suspicious: she is too good to be true. Every dish she serves turns out to be delicious, the whole residence sparkles after she cleans it, and all the clothing has given off a pleasant scent since she started doing the laundry. Furthermore, her devilishly beautiful eyes only serve to heighten Yuuri's suspicions. Is Lilith perhaps a witch or a sorcerer? Yuuri cannot figure it out. But despite his misgivings, Yuuri has to live with Lilith as he tries to unravel the mystery behind her otherworldly charm.

At a certain trading company, saleswoman Futaba Igarashi has managed to hold her respectable job for almost two years thanks to the guidance of her senior coworker—Harumi Takeda. However, due to Igarashi's short stature, Takeda often teases her and treats her like a kid, leaving Igarashi constantly annoyed by his antics. Despite this, Igarashi notices Takeda's reliability as he is always ready to help whenever something at their workplace goes awry. As Igarashi and Takeda spend more time together, their relationship soon develops further than simply being coworkers at the office.