Junichirou Kagami is a young published physicist, a genius, and a hopeless otaku. At the mercy of YD, a self-diagnosed illness which causes him to only be able to do what he Yearns to Do, Junichirou foregoes his scientific career to maintain and improve his anime blog. However, when he gets hired as a high school physics teacher; his sister Suzune, no longer willing to tolerate his NEET lifestyle, forces him to take the position. Despite the fact that Junichirou has no motivation to teach the standard curriculum, he may still have something of value to teach his students outside of academics. With his class in tow, Junichirou embarks on an unlikely journey filled with life lessons such as acceptance of others, how to make lasting friends, and what it means to live a better life by doing what you yearn to do.

With a stray pitch that completely missed the batter, Eijun Sawamura loses his final middle school baseball game. Frustrated by this defeat, Eijun and his teammates vow to reach the national tournament once they are in high school. But everything changes when a scout unexpectedly invites him to Tokyo's prestigious Seidou High School after seeing the potential in his unusual pitching style. Encouraged by his teammates, Eijun accepts the offer, ready to improve his skills and play at a much more competitive level of baseball. However, now surrounded by a large number of skilled players, Eijun struggles to find his place on the team. He declares that he will one day become the team's ace, but that's only if fellow first year Satoru Furuya doesn't take the title first, with his breakneck fastballs that earn him a coveted spot on the starting roster. With the addition of these talented new players to an already powerful lineup, the Seidou baseball team aims to become the best in Japan, facing off against a number of formidable foes that stand in their way.

The hallowed ground of Koshien Stadium is the field of dreams, where the ambitions of high school baseball players come true. After emerging victorious in the autumn tournament last year, Seidou High School baseball's team has finally earned the right to compete there for the first time in seven years. Beyond the spring tournament looms the battle to decide who is the best team in the nation — the Summer Koshien. With the third-year players due to retire after the summer tournament, the team has to integrate the experience of the seniors and the potential of the newcomers to overcome familiar and new opponents alike and win the coveted national title. Meanwhile, pitcher Eijun Sawamura is as determined as ever to earn jersey No. 1 and seize the position of ace from his persistent rival, Satoru Furuya. As the team prepares for their greatest challenge yet, Sawamura and Furuya carry on their struggle to lead their team to glory and become the star of the game: the true Ace of the Diamond.

Yui Komori, still held captive by the Sakamaki brothers—pureblood vampires after her blood—experiences yet more bizarre twists to her life following her stay at their household. Though haunted by enigmatic dreams, Yui soon deciphers their meaning when caught in a car crash, which subsequently leads to meeting four new vampires: the Mukami brothers, Ruki, Azusa, Kou, and Yuuma, who themselves capture the bewildered girl. Yui later awakens in the Mukami mansion, where the brothers reveal their plans for her: she is their Eve, and her blood will find the Adam among them; together, they will have the power to rule the world. However, with the Sakamaki brothers hot on their heels, things might not go quite as smoothly as they had imagined.